Secretion of MMP-9 is associated with macrophage-dependent Aβ degradation. Secretion of MMP-9 is associated with macrophage-dependent Aβ degradation. A,

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Secretion of MMP-9 is associated with macrophage-dependent Aβ degradation. Secretion of MMP-9 is associated with macrophage-dependent Aβ degradation. A, B, PDAPP brain sections were incubated with media alone (Control), macrophages (Macs), macrophages plus a polyclonal rabbit anti-mouse MMP-9 antibody (Macs + a′-MMP-9; 50 μg/ml), or macrophages plus an anti-rabbit sera (Macs + a′-sera; 50 μg/ml) for 96 h. C, D, PDAPP brain sections were incubated with media alone (Control), macrophages (Macs), or macrophages plus an MMP-9 inhibitor (Macs + MMP-9 In.; 10 μm) for 96 h. Aβ42 levels in the sections (A, C) or media (B, D) were measured by ELISA and are presented as a percentage of control value. n = 6 sections per treatment; ***p < 0.001 versus Control; #p < 0.05, ###p < 0.001 versus Macs. Expression of MMP-9 (green) in macrophages isolated from mice expressing human apoE2 (E2), apoE3 (E3), or apoE4 (E4). E, MMP-9 immunoreactive cells were quantified using Image-Pro Plus software. Cell nuclei visualized by DAPI (blue). Original magnification, 20×. **p < 0.01 versus E2. F, Gelatin-substrate zymography and quantitative analysis of MMP-9 and MMP-2 activity in media from apoE2 (E2)-, apoE3 (E3)-, or apoE4 (E4)-expressing macrophages incubated with (+ sections) or without (− sections) PDAPP brain sections. n = 6 sections per treatment; **p < 0.01, ***p < 0.001 versus apoE2 macrophages. Representative data from one experiment that was repeated three times with similar results. Error bars represent the SE measurement. Lingzhi Zhao et al. J. Neurosci. 2009;29:3603-3612 ©2009 by Society for Neuroscience