Thomas C. Dowling, Reginald F. Frye, Donald S. Fraley, Gary R. Matzke

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Characterization of tubular functional capacity in humans using para-aminohippurate and famotidine Thomas C. Dowling, Reginald F. Frye, Donald S. Fraley, Gary R. Matzke Kidney International Volume 59, Issue 1, Pages 295-303 (January 2001) DOI: 10.1046/j.1523-1755.2001.00491.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Plasma concentration versus time profile (mean ± SD) corresponding to the sequential para-aminohippuride (PAH) infusions (steps 1 through 4) for PAH (A) and acetyl-PAH (aPAH; B). Kidney International 2001 59, 295-303DOI: (10.1046/j.1523-1755.2001.00491.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Renal clearance values for PAH (A) and aPAH (B) during the sequential PAH infusions (steps 1 through 4). The horizontal bar indicates the mean renal clearance at each infusion step, and the stippled line indicates the mean GFR in the study subjects. Kidney International 2001 59, 295-303DOI: (10.1046/j.1523-1755.2001.00491.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Plot of the rate of tubular secretion (Rsec) relative to the plasma concentration of PAH in all subjects. Data points represent mean values ± SD. The solid line represents the mean of the fitted values of Km (141 mg/L) and TmPAH (71 mg/min/1.73 m2). Kidney International 2001 59, 295-303DOI: (10.1046/j.1523-1755.2001.00491.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Relationship between the rate of tubular secretion (Rsec) and the unbound concentration of famotidine in plasma. Data points indicate the Rsec values obtained during the last 90 minutes of the infusion. Symbols represent individual subjects. The solid line is the fitted least squares regression line (y = 0.37 × x - 2.3, r2 = 0.95, P < 0.001). Kidney International 2001 59, 295-303DOI: (10.1046/j.1523-1755.2001.00491.x) Copyright © 2001 International Society of Nephrology Terms and Conditions