COX-2 deletion in macrophages led to increased renal macrophage infiltration in diabetic mice. COX-2 deletion in macrophages led to increased renal macrophage.

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COX-2 deletion in macrophages led to increased renal macrophage infiltration in diabetic mice. COX-2 deletion in macrophages led to increased renal macrophage infiltration in diabetic mice. A: CCL2 (or MCP-1) mRNA levels were markedly increased in diabetic CD11b-Cre COX2f/f mice. *P < 0.05; n = 5–7. B: Renal macrophage infiltration (F4/80-positive cells) was markedly increased in diabetic CD11b-Cre COX2f/f mice. ***P < 0.001; n = 4. Original magnification: ×250. Xin Wang et al. Diabetes 2017;66:494-504 ©2017 by American Diabetes Association