Will Bailis, Justin A. Shyer, Michael Chiorazzi, Richard A. Flavell

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Presentation transcript:

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs Will Bailis, Justin A. Shyer, Michael Chiorazzi, Richard A. Flavell Cancer Cell Volume 32, Issue 3, Pages 280-281 (September 2017) DOI: 10.1016/j.ccell.2017.08.013 Copyright © 2017 Terms and Conditions

Figure 1 Fatty Acid Oxidation Enhances CD8+ T Cell Activation within the Tumor Microenvironment Effector CD8+ T cells exposed to hypoxic environments utilize glucose to generate energy and biosynthetic intermediates to maintain activation. Within the nutrient-restricted solid tumor microenvironment, where both oxygen and glucose availability is low, tumor-infiltrating CD8+ T cells reprogram to catabolize lipids to sustain effector function. Cancer Cell 2017 32, 280-281DOI: (10.1016/j.ccell.2017.08.013) Copyright © 2017 Terms and Conditions