Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens Riikka Uotila, MD, Anna.

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Presentation transcript:

Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens Riikka Uotila, MD, Anna Kaarina Kukkonen, MD, PhD, Dario Greco, PhD, Anna Susanna Pelkonen, MD, PhD, Mika Juhani Mäkelä, MD, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 4, Pages 1393-1396.e6 (April 2017) DOI: 10.1016/j.jaci.2016.09.054 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Serum peanut allergen-specific IgE measured with ISAC microarray before and after peanut OIT build-up phase. *Omitted from microarray data analysis. Only allergens with ≥50% + 1 patients sensitized (≥0.3 ISU-E) in ≥1of 4 groups (OIT pre, OIT post, avoidance pre, avoidance post) are included in order to ensure the representativeness of the given allergen. See the Methods in this article's Online Repository (available at www.jacionline.org). Journal of Allergy and Clinical Immunology 2017 139, 1393-1396.e6DOI: (10.1016/j.jaci.2016.09.054) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 IgG4-IgE ratios to peanut allergens and whole peanut extract measured with ImmunoCAP before and after peanut OIT build-up phase. Journal of Allergy and Clinical Immunology 2017 139, 1393-1396.e6DOI: (10.1016/j.jaci.2016.09.054) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Sensitization prevalences (%) to individual allergens in protein families cross-reactive to peanut. Journal of Allergy and Clinical Immunology 2017 139, 1393-1396.e6DOI: (10.1016/j.jaci.2016.09.054) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Changes in the levels of specific IgG4 to Ara h 2, Ara h 6, and whole peanut extract measured with ImmunoCAP in (A) OIT group and (B) avoidance group before and after peanut OIT build-up phase. Journal of Allergy and Clinical Immunology 2017 139, 1393-1396.e6DOI: (10.1016/j.jaci.2016.09.054) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions