Changes in sputum counts and airway hyperresponsiveness after budesonide: Monitoring anti-inflammatory response on the basis of surrogate markers of airway.

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Presentation transcript:

Changes in sputum counts and airway hyperresponsiveness after budesonide: Monitoring anti-inflammatory response on the basis of surrogate markers of airway inflammation Gaetano Prosperini, MDa, Kajakulasingam Rajakulasingam, MDb, Rossella R. Cacciola, MD, PhDc, Lucia Spicuzza, MDa, Steuart Rorke, MDb, Stephen T. Holgate, MDb, Giuseppe U. Di Maria, MDa, Riccardo Polosa, MD, PhDa Journal of Allergy and Clinical Immunology Volume 110, Issue 6, Pages 855-861 (December 2002) DOI: 10.1067/mai.2002.130050 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Changes in PC20 methacholine and PC20 AMP values expressed as mean ± SEM doubling dilutions after each 3-week treatment period with placebo (Pla ; open circles ) and budesonide (Bude ; filled circles ). *P < .05 and **P < .001 (after placebo vs after budesonide treatment). Journal of Allergy and Clinical Immunology 2002 110, 855-861DOI: (10.1067/mai.2002.130050) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Comparative changes in PC20 methacholine (filled circles) and PC20 AMP (open circles) values expressed as mean ± SEM doubling dilutions before, during, and after discontinuation of budesonide treatment. *P < .05, **P < .01, and ***P < .001 (after treatment vs baseline). Journal of Allergy and Clinical Immunology 2002 110, 855-861DOI: (10.1067/mai.2002.130050) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 Comparative changes in median (± interquartile range) percentage of eosinophil (open boxes) and epithelial cell (filled boxes) counts in the sputum before, during, and after discontinuation of budesonide treatment. Medians are shown as thick horizontal bars . *P < .05 and **P < .01 (after treatment vs baseline). Journal of Allergy and Clinical Immunology 2002 110, 855-861DOI: (10.1067/mai.2002.130050) Copyright © 2002 Mosby, Inc. Terms and Conditions