Anne Marie Singh, MD, Michael D

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Presentation transcript:

Expression patterns of atopic eczema and respiratory illnesses in a high-risk birth cohort Anne Marie Singh, MD, Michael D. Evans, MS, Ronald Gangnon, PhD, Kathy A. Roberg, MSN, Christopher Tisler, MS, Douglas DaSilva, BS, Tressa Pappas, BS, Lisa Salazar, BS, Elizabeth L. Anderson, MA, James E. Gern, MD, Robert F. Lemanske, MD, Christine M. Seroogy, MD Journal of Allergy and Clinical Immunology Volume 125, Issue 2, Pages 491-493.e4 (February 2010) DOI: 10.1016/j.jaci.2009.11.026 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Longitudinal assessment of wheezing and allergic sensitization. For the 3 AE groups, separate graphs depict the prevalence of wheezing illnesses (A), respiratory syncytial virus (RSV)–specific wheezing illnesses (B), and age-specific changes in any positive fluoroenzyme immunoassay (FEIA;C, ≥ 0.35 kU/L for food or aeroallergen) annually from birth to age 6 years. ∗P < .05 healthy/transient versus early recurrent; ‡P < .05 early/recurrent versus late-onset. Journal of Allergy and Clinical Immunology 2010 125, 491-493.e4DOI: (10.1016/j.jaci.2009.11.026) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Yearly prevalence of AE in the 3 groups: none/transient, late-onset, and early/recurrent. Latent class analysis models were estimated by using the yearly AE observations (years 1-6; Methods in the Online Repository). Children were grouped into 1 of 3 phenotypes. Black bars, None/transient AE; gray bars, late-onset AE; white bars, early/recurrent AE. Journal of Allergy and Clinical Immunology 2010 125, 491-493.e4DOI: (10.1016/j.jaci.2009.11.026) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Early allergen sensitization is associated with early/recurrent AE. Age-specific changes in the prevalence of food specific IgE (A), the prevalence of aeroallergen specific IgE (B), and total IgE (C) in the 3 AE groups. Closed diamond, None/transient AE; open square, late-onset AE; closed triangle, early/recurrent AE. ∗P <.05 healthy/transient versus early recurrent; ‡P <.05 early/recurrent versus late-onset. FEIA, Fluoroenzyme immunoassay. Journal of Allergy and Clinical Immunology 2010 125, 491-493.e4DOI: (10.1016/j.jaci.2009.11.026) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Children with early/recurrent AE are most likely to develop additional atopic diseases. Prevalence of asthma at year 6 (A), allergic rhinitis at year 6 (B), and positive skin tests at year 5 (C) in children with each AE phenotype. Black bar, Healthy/transient AE; gray bar, late-onset AE; white bar, early/recurrent AE. ∗P <.05. Journal of Allergy and Clinical Immunology 2010 125, 491-493.e4DOI: (10.1016/j.jaci.2009.11.026) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions