Fig. 4. Reduction of apoptosis and autophagic stress by treatment with silibinin in the KA-treated hippocampus. (A, B) Double-immunofluorescence staining.

Slides:

Advertisements

Similar presentations

Invest. Ophthalmol. Vis. Sci ;49(10): doi: /iovs Figure Legend:

Advertisements

FMRP suppresses dendritic Arc protein levels.

Iron citrate reduces high phosphate-induced vascular calcification by inhibiting apoptosis Paola Ciceri, Francesca Elli, Paola Braidotti, Monica Falleni,

Fig. 2. The expression of pKr-2 in the substantia nigra (SN) of patients with Parkinson's disease (PD). (A, B) Western blot analysis for pKr-1-2 and pKr-2,

Supplementary Fig. 1 *** Cell viability (%) HepG2 3 (hr) DU145 A549 17

Fig. 3. Expression of Ninj1protein in cortices of the ischemic hemispheres of the rat brain at 4 day post-MCAO. Coronal brain sections were prepared at.

Activation of Src Family Kinases in Spinal Microglia Contributes to Formalin-Induced Persistent Pain State Through p38 Pathway Yong-Hui Tan, Kai Li,

Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of.

Cx43 Mediates Resistance against MPP+ -Induced

Copyright © 2008 American Medical Association. All rights reserved.

Fig. 5. The measurement of phosphorylation of p53 level in N2A cells under high glucose condition and agmatine treatment. (A, B) p53 phosphorylation levels.

Fig. 2. Expressions of TMEM16A and MUC5AC proteins in dissociated human sinonasal epithelium. (A) The expression of TMEM16A protein was detected by Western.

Fig. 1. Infarct size and behavioral outcomes in response to single and repeated treatment of hUCB-MSCs after MCAO. (A) Schematic of the time schedule.

Fig. 2. Infection by lentivirus

Fig. 2. Expression of Ninj1 in cortices of ischemic hemispheres of rat brains at 1 day post-MCAO. Coronal brain sections were prepared at 1 day post-MCAO.

Figure 1 Body weight of control and BPA-treated mothers after delivery

Prodifferentiation, Anti-Inflammatory and Antiproliferative Effects of Delphinidin, a Dietary Anthocyanidin, in a Full-Thickness Three-Dimensional Reconstituted.

High molecular weight hyaluronic acid regulates osteoclast formation by inhibiting receptor activator of NF-κB ligand through Rho kinase W. Ariyoshi,

Amanda M. Nelson, Kathryn L. Gilliland, Zhaoyuan Cong, Diane M

T. Minashima, K.A. Campbell, S.R. Hadley, Y. Zhang, T. Kirsch

H. Wang, Y. Dong, J. Zhang, Z. Xu, G. Wang, C. A. Swain, Y. Zhang, Z

Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression

Volume 142, Issue 1, Pages e2 (January 2012)

Regulation of MAPK Activation, AP-1 Transcription Factor Expression and Keratinocyte Differentiation in Wounded Fetal Skin Samantha Gangnuss, Allison.

Volume 88, Issue 3, Pages (November 2015)

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy

Chd5 deficiency in NSCs leads to premature activation.

Hypoxia Impairs Skin Myofibroblast Differentiation and Function

L. Tong, M. Cai, Y. Huang, H. Zhang, B. Su, Z. Li, H. Dong

Relative mRNA expression level (/J3T-1)

PMI: A ΔΨm Independent Pharmacological Regulator of Mitophagy

Volume 11, Issue 4, Pages (October 2018)

Disrupted dynamics of early stages of differentiation perturbs neural cell fate specification. Disrupted dynamics of early stages of differentiation perturbs.

Estrogenic regulation of testicular expression of stem cell factor and c-kit: implications in germ cell survival and male fertility Sara Correia, M.S.,

Single sevoflurane exposure decreases neuronal nitric oxide synthase levels in the hippocampus of developing rats X. Feng, J.J. Liu, X. Zhou, F.H. Song,

Nec‐1 inhibits the phosphorylation and aggregation of tau

Nicotine inhibits hippocampal and striatal acetylcholinesterase activities, and demonstrates dual action on adult neuronal proliferation and maturation

Survival and death-promoting events after transient spinal cord ischemia in rabbits: Induction of Akt and caspase3 in motor neurons Masahiro Sakurai,

Volume 26, Issue 1, Pages (January 2018)

Activin Signals through SMAD2/3 to Increase Photoreceptor Precursor Yield during Embryonic Stem Cell Differentiation Amy Q. Lu, Evgenya Y. Popova, Colin.

Volume 26, Issue 8, Pages (August 2018)

EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy

Volume 1, Issue 4, Pages (April 2012)

Alpha-synuclein induces autophagy in microglial cells.

Adenosine-induced osteogenic differentiation of hiPSCs involves A2bR

Fig. 1. Effects on the tight junction barrier and permeability following doxorubicin and Herceptin treatment. Effects on the tight junction barrier and.

Fgfr3;4 mutant lungs display an increase in Mfap5, Igf1 and Fbn2 expression. Fgfr3;4 mutant lungs display an increase in Mfap5,Igf1and Fbn2 expression.

AAS-dependent induction of autophagic flux in ARPE-19.

Fig. 2. Acetylation stiffens primary cilia.

Fig. 1. Cell adhesion molecule expression and the aggregation of wildtype and mutant ES cells.(A) Wildtype (WT), E-cadherin null (9J), and N-cadherin null.

P.J. Moss, W. Huang, J. Dawes, K. Okuse, S.B. McMahon, A.S.C. Rice

Fig. 3. Neuroprotective effects of silibinin against KA-induced excitotoxicity. (A) Silibinin was intraperitoneally injected for 8 days, starting 1 day.

Fig. 5. Anti-inflammatory effects of silibinin on KA treatment in the hippocampus. (A) Representative coronal sections of the hippocampal CA1 region following.

Microglia activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal.

Western blot of MDA-modified proteins in FVB control, OVE26 diabetic, and catalase-protected OVE26C diabetic hearts. Western blot of MDA-modified proteins.

Fig. 2. Induction of F-actin polymerization by OPNpt20

Fig. 3. Inhibition of HIF1α with chrysin induced cell death and suppressed the expressions of glycolysis-regulating genes in GBMs. (A~D) Cell viability.

Fig. 1. Changes in hippocampal matrix metalloproteinase-9 (MMP-9) and angiopoietin-2 (ANG-2) expression over time following bilateral common carotid artery.

Interaction of aggregates with CAF network structures.

Fig. 2. TH expression is decreased in mice with HFD-induced obesity

FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression. FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression.

Fig. 3. KMS99220 inhibits activation of NFκB signaling via HO-1 induction. (A) BV2 cells were treated with 10 µM KMS99220 for 1 h, and then treated with.

Fig. 3. LPS induces degeneration of DA neurons and microglial activation in the SN in vivo. LPS (5 µg/3 µl) was unilaterally injected into the SN in the.

Fig. 3. Ultra-wide-field color FP and AF, spectral-domain OCT, and H&E staining images at one month after intravitreal MNU injection with pars plana vitrectomy.

Fig. 5 C9orf72 knockdown disrupts autophagy induction.

Fig. 3. hALDH1L1 promoter-driven Cre recombinase-mediated tdTomato expression in BLA. (A) Low magnification images of injection area in amygdala. Each.

Fig. 1. Differential activity-induced secretion of overexpressed BDNF from cortical axons or striatal neurites in the normal or Q140 heterozygote mice.

Fig. 5. Phagocytosis of zymosan particles by BV2 cells

Identification of Kinases Responsible for p53-Dependent Autophagy

Presentation transcript:

Fig. 4. Reduction of apoptosis and autophagic stress by treatment with silibinin in the KA-treated hippocampus. (A, B) Double-immunofluorescence staining for NeuN (green) and c-caspase-3 (red), and NeuN (green) and c-PARP-1 (red) in the hippocampal CA1 region 2 days after KA treatment. Insets delimited by the solid line in the panels on the right show high magnification portions of the image. Scale bars are given for both the main image (40x) and insets (100x): 20 µm and 10 µm. (C, D) Western blot analysis of c-caspase-3, caspase-3, c-PARP-1, and PARP-1 expression in the hippocampus 2 days after KA treatment. The density of c-caspase-3, caspase-3, c-PARP-1, and PARP-1 bands was normalized to the β-actin band for each sample. *p<0.001 and **p<0.01 vs. PBS alone, #p<0.01 vs. KA alone (one-way ANOVA and Tukey's post-hoc analysis; n=4, each experimental group). All values are expressed as the mean±SEM. (E) Double-immunofluorescence staining for NeuN (green) and LC3B (red) in the hippocampal CA1 region 2 days after KA treatment. Scale bars are given for both the main image (40x) and insets (100x): 20 µm and 10 µm. (F, G) Western blot analysis of LC3 in the hippocampus 2 days after KA treatment. The density of LC3-II band was normalized to the β-actin band for each sample. *p<0.001 vs. PBS alone, #p<0.001 vs. KA alone (one-way ANOVA and Tukey's post-hoc analysis; n=4, each experimental group). All values are expressed as the mean±SEM. Fig. 4. Reduction of apoptosis and autophagic stress by treatment with silibinin in the KA-treated hippocampus. (A, B) Double- immunofluorescence staining for NeuN (green) and c-caspase-3 (red), and NeuN (green) and c-PARP-1 (red) in the hippocampal CA1 region 2 days after KA treatment. Insets delimited by the solid line in the panels… Exp Neurobiol. 2017 Oct;26(5):266-277. https://doi.org/10.5607/en.2017.26.5.266