MK-8628 augments T lymphocyte apoptosis.

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MK-8628 augments T lymphocyte apoptosis. MK-8628 augments T lymphocyte apoptosis. (A) Flow cytometry contour plots of annexin V and PI staining in anti-CD3/CD28 mAb–stimulated CD4+ and CD8+ T lymphocytes treated with 0.19 μM MK-8628 or untreated controls after 96 h. (B) Dose response depicting frequency of annexin V/PI, double-positive, late-stage apoptotic cells as show in (A). (C) Flow cytometry contour plots of the fluorescent pan-caspase inhibitor FITC-VAD-FMK in anti-CD3/CD28 mAb–stimulated CD4+ and CD8+ T lymphocytes treated with 0.19 μM MK-8628 or untreated controls after 96 h. (D) Dose response depicting frequency FITC-VAD-FMK positive cells as shown in (C). Data are from one experimental representative of at least three independent experiments and represent triplicate wells; small horizontal red lines indicate the mean. **p < 0.01, ***p < 0.001, ****p < 0.0001, one-way ANOVA with posttest analysis. Peter Georgiev et al. ImmunoHorizons 2019;3:294-305 Copyright © 2019 The Authors