Figure 1 Analysis of inflammatory cells in muscle biopsies

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Figure 1 Analysis of inflammatory cells in muscle biopsies Analysis of inflammatory cells in muscle biopsies (A) Pattern of analysis with evaluation of endo- and perimysial immunoreactivity separately for each group (1–4) and positive controls (B–I) Dot blots showing the comparison of muscle biopsies from patients with myalgia only (group 1, n = 24), hyperCKemia only (group 2, n = 26), myalgia and pathologic EMG (group 3, n = 9), and normal muscle biopsies from asymptomatic MH-negative patients (group 4, n = 12) concerning the frequency of CD3+, CD4+, and CD8+ T-lymphocytes and of CD68+ macrophages (immunoreactive cells/mm2). Biopsies of patients with dermatomyositis (DM) (n = 5), polymyositis (PM) (n = 4), and inclusion body myositis (IBM) (n = 4) were used as positive controls. The central horizontal bars denote the median value. **p < 0.01; ***p < 0.001. DM = dermatomyositis; IBM = inclusion body myositis; PM = polymyositis. Kirsten Johannssen et al. Neurol Neuroimmunol Neuroinflamm 2019;6:e549 Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.