EPA treatment rescued LPL RNAi–induced suppression of MTCOI protein expression. EPA treatment rescued LPL RNAi–induced suppression of MTCOI protein expression. L6 myotubes were incubated with EPA (50 μmol/L), DHA (50 μmol/L), or 0.125% BSA for 48 h after LPL and CD36 RNAi treatment (50 nmol/L). MTCOI protein expressions were measured by Western blotting (n = 9). Results represent mean ± SEM. *P < 0.05, ***P < 0.0005. Katsutaro Morino et al. Diabetes 2012;61:877-887 ©2012 by American Diabetes Association