Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients Eric R. Siemers, Karen L. Sundell, Christopher Carlson, Michael Case,

Slides:

Advertisements

Similar presentations

Do Instrumental Activities of Daily Living Predict Dementia at 1- and 2- Year Follow-Up? Findings from the Development of Screening Guidelines and Diagnostic.

Advertisements

Psychosis in Dementia Conclusions Psychosis in dementia is distressful and disturbing to patients and  Is similar across the spectrum of the dementia.

Mild Cognitive Impairment, Activity Participation, Functional Difficulty, and Adaptations in Functionally Vulnerable Elderly People: A Closer Look Laraine.

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Date of download: 7/8/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Intranasal Insulin Therapy for Alzheimer Disease and.

DIAGNOSTIC ACCURACY AND CONFIDENCE IN THE CLINICAL DETECTION OF COGNITIVE IMPAIRMENT IN EARLY-STAGE PARKINSON’S DISEASE Kathryn A. Wyman-Chick, Phillip.

Aka STEEL VALLEY SENIORS SURVEY (SVSS)

Volume 1, Issue 1, Pages (June 2015)

Volume 3, Issue 4, Pages (November 2017)

Volume 3, Issue 1, Pages 1-9 (January 2017)

Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease Azadeh Karami, Helga Eyjolfsdottir, Swetha.

A SYSTEMATIC REVIEW AND META-ANALYSIS COMPARING QUALITY-OF-LIFE RATINGS FROM FAMILY AND PAID CAREGIVERS OF PEOPLE WITH DEMENTIA RESIDING IN CARE HOMES

Cognitive Interventions in Mild Alzheimer's Disease: A Therapy-Evaluation Study on the Interaction of Medication and Cognitive Treatment Dement Geriatr.

Bo Karlsson, Gunilla Burell, Ulla-Maria Anderberg, Kurt Svärdsudd

From ESH 2016 | POS 3C: Chiara Lorenzi, MD

Tai Chi Exercise for Cancer-Related Fatigue in Patients With Lung Cancer Undergoing Chemotherapy: A Randomized Controlled Trial Li-Li Zhang, RN, Su-Zhen.

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Two configurations of static magnetic fields for treating rheumatoid arthritis of the knee: A double-blind clinical trial Neil A. Segal, MD, Yoshitaka.

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Longitudinal evaluation of criteria for subjective cognitive decline and preclinical Alzheimer's disease in a memory clinic sample Marie Eckerström,

The differential diagnosis of amnestic mild cognitive impairment and Alzheimer's disease dementia by hippocampal volume measurement with MR in a chinese.

Preventive Effect of Rifampicin on Alzheimer Disease Needs at Least 450 mg Daily for 1 Year: An FDG-PET Follow-Up Study - DOI: / Fig. 1.

Detecting functional decline from normal aging to dementia: Development and validation of a short version of the Amsterdam IADL Questionnaire Roos J.

Christine Bredfeldt, Kristen Rice, Lisa Alecxih

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Frailty syndrome and the risk of vascular dementia: The Italian Longitudinal Study on Aging Vincenzo Solfrizzi, Emanuele Scafato, Vincenza Frisardi,

Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review Christian Thoma, Christopher P. Day, Michael.

Volume 3, Issue 1, Pages (January 2017)

Ben Sherwood, Andrew Xiao-Hua Zhou, Sandra Weintraub, Lan Wang

Early diagnosis of mild cognitive impairment and Alzheimer's disease based on salivary lactoferrin Eva Carro, Fernando Bartolomé, Félix Bermejo-Pareja,

ADI Disease International 7-10 March, 2012

Early Dementia Distinguishing AD From MCI

Alzheimer's disease drug development pipeline: 2018

11/30/2018 Using Delayed Start Design and Analysis to Investigate Potential Disease Modifying Effects in Alzheimer’s Disease.

Tai Chi Exercise for Cancer-Related Fatigue in Patients With Lung Cancer Undergoing Chemotherapy: A Randomized Controlled Trial Li-Li Zhang, RN, Su-Zhen.

Effective treatment of house dust mite–induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: Results from a randomized, double-blind, placebo-controlled.

The efficacy of 12 weeks non-surgical treatment for patients not eligible for total knee replacement: a randomized controlled trial with 1-year follow-up

Systematic Review and Meta-Analysis of Combination Therapy with Cholinesterase Inhibitors and Memantine in Alzheimer’s Disease and Other Dementias Dement.

Martin R. Farlow, MD Mayo Clinic Proceedings

Mental imagery for promoting relearning for people after stroke: A randomized controlled trial1 Karen P. Liu, PhD, Chetwyn C. Chan, PhD, Tatia M. Lee,

Redefining Appropriate Treatment Expectations

Ara S. Khachaturian, David P

Steven D. Targum, Christopher J. Catania

Tharick A. Pascoal, Sulantha Mathotaarachchi, Monica Shin, Andrea L

Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study Kumar B. Rajan, Jennifer Weuve,

A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee

The Mini-Mental State Examination and Montreal Cognitive Assessment in Persons With Mild Subacute Stroke: Relationship to Functional Outcome Joan Toglia,

The validity of the Memory Alteration Test and the Test Your Memory test for community- based identification of amnestic mild cognitive impairment Seline.

Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study Kumar B. Rajan, Jennifer Weuve,

Volume 17, Issue 2, Pages (February 1950)

Todd R. Vogel, MD, MPH, Gregory F. Petroski, PhD, Robin L. Kruse, PhD

Schematic representation of core elements of geriatric assessment.

LIFESPAN OF ONE FOCUSED ULTRASOUND MEDIATED BLOOD-BRAIN BARRIER TREATMENT IN A MOUSE MODEL OF ALZHEIMER'S DISEASE Charissa Poon, Kullervo Hynynen Alzheimer's.

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective Matthew Baumgart, Heather M. Snyder,

Safety and efficacy of a fixed combination of halobetasol and tazarotene in the treatment of moderate-to-severe plaque psoriasis: Results of 2 phase 3.

Interreg-IPA Cross-border Cooperation Programme Romania-Serbia

Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down Eric D. Bateman, MD, Loretta Jacques, PhD,

A biomarker signal: Context-dependent hippocampal fMRI connectivity analysis of clinical trial measures in Alzheimer's disease Donald McLaren, Reisa.

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease W. Robert Bell, Yang An,

Eckard Hamelmann, MD, Eric D

Tezepelumab, an anti–thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a.

Two configurations of static magnetic fields for treating rheumatoid arthritis of the knee: A double-blind clinical trial Neil A. Segal, MD, Yoshitaka.

Increased risk for dementia both before and after stroke: A population-based study in women followed over 44 years Xinxin Guo, Svante Östling, Silke.

The Propranolol Aneurysm Trial Investigators

Michael Navitsky, Abhinay D. Joshi, Michael D. Devous, Michael J

Osteoarthritis and Cartilage

CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER.

Apremilast, an oral phosphodiesterase-4 inhibitor, in the treatment of palmoplantar psoriasis: Results of a pooled analysis from phase II PSOR-005 and.

Susan D. Rountree, Alireza Atri, Oscar L. Lopez, Rachelle S. Doody

Fig. 1. ROC curve for K-IADL to diagnose dementia or MCI

Presentation transcript:

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients Eric R. Siemers, Karen L. Sundell, Christopher Carlson, Michael Case, Gopalan Sethuraman, Hong Liu-Seifert, Sherie A. Dowsett, Michael J. Pontecorvo, Robert A. Dean, Ronald Demattos Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 12, Issue 2, Pages 110-120 (February 2016) DOI: 10.1016/j.jalz.2015.06.1893 Copyright © 2016 Eli Lilly and Company, Indianapolis, IN Terms and Conditions

Fig. 1 Flow of study subjects. aDisease severity was based on baseline MMSE score (mild, MMSE 20–26; moderate, MMSE 16–19). Baseline MMSE was outside of the study eligibility range (>26) for some randomized subjects, and these individuals were not categorized based on disease severity nor included in pooled mild-AD data set. Abbreviations: MMSE, Mini-Mental State Examination; AD, Alzheimer's disease; lab, laboratory measure; ECG, echocardiogram. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, 110-120DOI: (10.1016/j.jalz.2015.06.1893) Copyright © 2016 Eli Lilly and Company, Indianapolis, IN Terms and Conditions

Fig. 2 LS mean change from baseline in (A) ADAS-Cog11, (B) ADAS-Cog14, (C) MMSE, (D) ADCS-ADL, (E) ADCS-iADLs, (F) ADCS-bADLs, and (G) CDR-SB over the 80-week study period for the mild AD study population. P values shown where P < .05 for difference between treatment groups at any time point and for difference between groups at 80 weeks. Error bars represent standard error. Arrows show direction for cognitive or functional decline. Abbreviations: ADAS-Cog, Alzheimer's Disease Assessment Scale–Cognitive subscale (11 item and 14 item); MMSE, Mini-Mental State Examination; ADCS-ADL, Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory; ADCS-iADL, ADCS-ADL Instrumental ADLs; ADCS-bADL, ADCS-ADL Basic ADLs; CDR-SB, Clinical Dementia Rating Sum of Boxes. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, 110-120DOI: (10.1016/j.jalz.2015.06.1893) Copyright © 2016 Eli Lilly and Company, Indianapolis, IN Terms and Conditions