Swollen Nuclei Signal from the Grave

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Swollen Nuclei Signal from the Grave Wakam Chang, Gregg G. Gundersen Cell Volume 165, Issue 5, Pages 1051-1052 (May 2016) DOI: 10.1016/j.cell.2016.05.015 Copyright © 2016 Terms and Conditions

Figure 1 Ca2+ Release and Nuclear Swelling Trigger Translocation of cPLA2 Cell lysis or swelling causes cytosolic Ca2+ release and nucleus swelling, both essential for cPLA2 activation. Mechanical changes of the nuclear membrane allow nucleoplasmic cPLA2 and 5-LOX to translocate to nuclear membrane to initiate eicosanoid biosynthesis and inflammatory responses. Cell 2016 165, 1051-1052DOI: (10.1016/j.cell.2016.05.015) Copyright © 2016 Terms and Conditions