BRCA1 and BRCA2 Testing: Weighing the Demand against the Benefits

Slides:



Advertisements
Similar presentations
Novel PMS2 Pseudogenes Can Conceal Recessive Mutations Causing a Distinctive Childhood Cancer Syndrome Michel De Vos, Bruce E. Hayward, Susan Picton, Eamonn.
Advertisements

Nuclear and Mitochondrial DNA Analysis of a 2,000-Year-Old Necropolis in the Egyin Gol Valley of Mongolia Christine Keyser-Tracqui, Eric Crubézy, Bertrand.
Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and.
Connexin Mutations in Skin Disease and Hearing Loss David P. Kelsell, Wei-Li Di, Mark J. Houseman The American Journal of Human Genetics Volume 68, Issue.
Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.
Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.
SORVEGLIANZA DELLE MALATTIE NEOPLASTICHE. Cancer statistics, 2013 CA: A Cancer Journal for Clinicians Volume 63, Issue 1, pages 11-30, 17 JAN 2013 DOI:
De Novo BRCA1 Mutation in a Patient with Breast Cancer and an Inherited BRCA2 Mutation Andrea Tesoriero, Chris Andersen, Melissa Southey, Gino Somers,
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis Douglas F. Levinson, Matthew D. Levinson, Ricardo Segurado,
Genomewide Comparison of DNA Sequences between Humans and Chimpanzees Ingo Ebersberger, Dirk Metzler, Carsten Schwarz, Svante Pääbo The American Journal.
Fragile X and X-Linked Intellectual Disability: Four Decades of Discovery Herbert A. Lubs, Roger E. Stevenson, Charles E. Schwartz The American Journal.
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.
The Duty to Recontact: Attitudes of Genetics Service Providers Jennifer L. Fitzpatrick, Cecil Hahn, Teresa Costa, Marlene J. Huggins The American Journal.
Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.
PRIMUS: Rapid Reconstruction of Pedigrees from Genome-wide Estimates of Identity by Descent Jeffrey Staples, Dandi Qiao, Michael H. Cho, Edwin K. Silverman,
Peopling of Sahul: mtDNA Variation in Aboriginal Australian and Papua New Guinean Populations Alan J. Redd, Mark Stoneking The American Journal of Human.
Evidence for Autosomal Dominant Inheritance of Prostate Cancer
MP60-03 PROSTATE CANCER IN THE ELDERLY
National Guidelines for Nursing Delegation
The Trimmed-Haplotype Test for Linkage Disequilibrium
Anna Middleton, J. Hewison, R.F. Mueller 
Statistical Considerations for Immunohistochemistry Panel Development after Gene Expression Profiling of Human Cancers  Rebecca A. Betensky, Catherine.
Transmission/Disequilibrium Tests for Extended Marker Haplotypes
Anna Middleton, J. Hewison, R.F. Mueller 
Daniel J. Schaid, Charles M. Rowland, David E. Tines, Robert M
Jacek Majewski  The American Journal of Human Genetics 
The APC I1307K Allele and BRCA-Associated Ovarian Cancer Risk
Next-Generation Sequencing: Methodology and Application
Optimized Group Sequential Study Designs for Tests of Genetic Linkage and Association in Complex Diseases  Inke R. König, Helmut Schäfer, Hans-Helge Müller,
Microarray Technique, Analysis, and Applications in Dermatology
CHEK2*1100delC and Susceptibility to Breast Cancer: A Collaborative Analysis Involving 10,860 Breast Cancer Cases and 9,065 Controls from 10 Studies 
2016 Curt Stern Award Address: From Rare to Common Diseases: Translating Genetic Discovery to Therapy1  Brendan Lee  The American Journal of Human Genetics 
Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined.
Ren-Hua Chung, Richard W. Morris, Li Zhang, Yi-Ju Li, Eden R. Martin 
Linkage Thresholds for Two-stage Genome Scans
Shih-Jen Hwang, Guillermina Lozano, Christopher I. Amos, Louise C
A Combined Linkage-Physical Map of the Human Genome
Genetics, Individuality, and Medicine in the 21st Century*
Frank Detterbeck, MD  Journal of Thoracic Oncology 
XMCPDT Does Have Correct Type I Error Rates
SLEN2 (2q34–35) and SLEN1 (10q22.3) Replication in Systemic Lupus Erythematosus Stratified by Nephritis  Ana I. Quintero-Del-Rio, Jennifer A. Kelly, C.
Quality improvement for the gastroenterology fellow
Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and.
A nationwide survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients  Eric J. Forman, M.D.,
Anne Dørum, Ketil Heimdal, Eivind Hovig, Mats Inganäs, Pål Møller 
Designer Lipids Advance Systemic siRNA Delivery
The SNP Endgame: A Multidisciplinary Approach*
Family-Based Tests of Association in the Presence of Linkage
Erratum The American Journal of Human Genetics
Suzanne M. Leal, Jurg Ott  The American Journal of Human Genetics 
Meiotic Microdeletion Breakpoints in the BRCA1 Gene Are Significantly Associated with Symmetric DNA-Sequence Elements  Beatrice Schmucker, Michael Krawczak 
Greg L. Loeben, Theresa M. Marteau, Benjamin S. Wilfond 
Alexander Liede, Imtiaz A
Organization news Archives of Physical Medicine and Rehabilitation
European Lung Cancer Conference (ELCC) 2016 Organisation
History of Oncolytic Viruses: Genesis to Genetic Engineering
The Journal of Thoracic and Cardiovascular Surgery
Discussion The Journal of Thoracic and Cardiovascular Surgery
Frequency and Carrier Risk Associated with Common BRCA1 and BRCA2 Mutations in Ashkenazi Jewish Breast Cancer Patients  Flora H. Fodor, Ainsley Weston,
Markers for Mapping by Admixture Linkage Disequilibrium in African American and Hispanic Populations  Michael W. Smith, James A. Lautenberger, Hyoung.
Giovanni Parmigiani, Donald A. Berry, Omar Aguilar 
Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases  Hugues Aschard, Jinbo.
On the Etruscan Mitochondrial DNA Contribution to Modern Humans
Evidence for Autosomal Dominant Inheritance of Prostate Cancer
Alice S. Whittemore, Jerry Halpern 
Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening  Hon-Cheong So, Johnny S.H.
Anna Middleton, J. Hewison, R.F. Mueller 
Sanjay Shete, Xiaojun Zhou, Christopher I. Amos 
Zuoheng Wang, Mary Sara McPeek  The American Journal of Human Genetics 
Kung-Yee Liang, Fang-Chi Hsu, Terri H. Beaty, Kathleen C. Barnes 
Presentation transcript:

BRCA1 and BRCA2 Testing: Weighing the Demand against the Benefits P. Devilee  The American Journal of Human Genetics  Volume 64, Issue 4, Pages 943-948 (April 1999) DOI: 10.1086/302350 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Comparison of cumulative breast cancer risk estimates conferred by BRCA1 and BRCA2. The estimates of the Breast Cancer Linkage Consortium are taken from Ford et al. (1995; 1998), whereas those for the 185delAG mutation in BRCA1 and the 999del5 mutation in BRCA2 were taken from Struewing et al. (1997) and Thorlacius et al. (1998), respectively. The American Journal of Human Genetics 1999 64, 943-948DOI: (10.1086/302350) Copyright © 1999 The American Society of Human Genetics Terms and Conditions