CD4+CLA+CD103+T cells from human blood and skin share a functional profile. CD4+CLA+CD103+T cells from human blood and skin share a functional profile.

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Presentation transcript:

CD4+CLA+CD103+T cells from human blood and skin share a functional profile. CD4+CLA+CD103+T cells from human blood and skin share a functional profile. (A) Representative flow cytometric analysis of CD103 and CLA expression by live gated CD4+CD45RA− T cells from blood and skin of healthy donors. (B to D) Representative flow cytometric analysis of indicated CLA/CD103 subpopulations of blood and skin CD4+CD45RA− T cells producing IL-13, IL-4, IL-22, IL-17A, IFN-γ, and GM-CSF as indicated upon ex vivo stimulation with PMA/ionomycin and intracellular cytokine staining. (E) Graphical summary of the proportions of CLA−CD103−, CLA+CD103−, and CLA+CD103+ live gated CD4+CD45RA− T cells producing cytokines as indicated. Open symbols represent data from an individual with mammary carcinoma. Significance was determined by one-way repeated-measures ANOVA with Tukey’s posttest for pairwise comparisons. Maria M. Klicznik et al. Sci. Immunol. 2019;4:eaav8995 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works