TSC1 knockdown enhances hypoxia-mediated lymphocyte death via mTORC1 activation TSC1 knockdown enhances hypoxia-mediated lymphocyte death via mTORC1 activation.

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Cell Physiol Biochem 2014;33: DOI: /

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TSC1 knockdown enhances hypoxia-mediated lymphocyte death via mTORC1 activation TSC1 knockdown enhances hypoxia-mediated lymphocyte death via mTORC1 activation (A) MTT assay showed that hypoxia reduces cell viability in hypoxia lymphocytes, whereas TSC1 knockdown enhances the cell death. Rapamycin treatment may rescue TSC1 knockdown-mediated cell death in hypoxia lymphocytes. (B–C) Western blots and quantifications showed that hypoxia induces cleaved caspase-3 protein levels and TSC1 knockdown enhances it. Rapamycin treatment may rescue TSC1 knockdown-induced cleaved caspase-3 in hypoxia lymphocytes. Results are averages of three independent experiments. Data represent mean ± S.E.M.; **P<0.01. Geng Yin et al. Biosci. Rep. 2017;37:BSR20160479 ©2017 by Portland Press Ltd