USP2–45 regulates hepatic gluconeogenesis.

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USP2–45 regulates hepatic gluconeogenesis. USP2–45 regulates hepatic gluconeogenesis. A: Plasma glucose and insulin concentrations in transduced mice measured under fed condition (ZT5). B: PTT in mice transduced with GFP (open squares, n = 7) or USP2–45 (filled triangles, n = 7) adenovirus. C: qPCR analysis of PEPCK and G6Pase gene expression in livers from mice transduced with GFP (open) or USP2–45 (filled) adenovirus. Data in A-C are means ± SEM. *P < 0.05, GFP vs. USP2–45. D: Blood glucose and insulin levels in mice transduced with control or siUSP2 adenovirus following overnight fast (ZT5). E: PTT in mice transduced with control (open squares, n = 6) or siUSP2 (filled triangles, n = 7) adenovirus. F: qPCR analysis of liver gene expression from mice transduced with control (open) or siUSP (filled) adenovirus. Data in D-F are means ± SEM. *P < 0.05, control vs. siUSP2. Matthew M. Molusky et al. Diabetes 2012;61:1025-1035 ©2012 by American Diabetes Association