Fighting Malaria: Mosquitoes Know How Bruce Beutler  Immunity  Volume 25, Issue 4, Pages 530-531 (October 2006) DOI: 10.1016/j.immuni.2006.10.001 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 The Ookinete and Its Vulnerability to TEP1 Arising from the fusion of male and female gametocytes, the zygote yields ookinetes that penetrate the wall of the midgut asynchronously, over a period of 16 to 20 hr. This process is resisted by “basal immunity,” under the control of transcription factors Rel1 and Rel2, and leads to a state of “induced immunity.” Induced immunity permits replenishment of parasite-killing factors such as TEP1. Immunity 2006 25, 530-531DOI: (10.1016/j.immuni.2006.10.001) Copyright © 2006 Elsevier Inc. Terms and Conditions