Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging  Nicole G.M. Beckers, M.D., Nicholas S. Macklon, Ph.D., Marinus J.C. Eijkemans, M.Sc., Bart C.J.M. Fauser, Ph.D.  Fertility and Sterility  Volume 78, Issue 2, Pages 291-297 (August 2002) DOI: 10.1016/S0015-0282(02)03227-2

FIGURE 1 The number of antral follicles present throughout the follicular phase is shown. The grey area depicts the 25th- and 75th-percentile amounts of the healthy controls, the black lines depict median and 25th- and 75th-percentile amounts of poor responders. Beckers. The follicular phase in poor responders. Fertil Steril 2002. Fertility and Sterility 2002 78, 291-297DOI: (10.1016/S0015-0282(02)03227-2)

FIGURE 2 Follicular phase serum levels of FSH, LH, E2, and P. The gray areas depict the 25th- and 75th-percentile levels of the healthy controls; the black lines depict median and 25th- and 75th-percentile levels of poor responders. Beckers. The follicular phase in poor responders. Fertil Steril 2002. Fertility and Sterility 2002 78, 291-297DOI: (10.1016/S0015-0282(02)03227-2)

FIGURE 3 The association between age and number of follicles overall and for poor responders (•) and healthy controls (○). The gray area indicates the overlap of age in the poor-responder and the healthy-control groups. Beckers. The follicular phase in poor responders. Fertil Steril 2002. Fertility and Sterility 2002 78, 291-297DOI: (10.1016/S0015-0282(02)03227-2)