Lung-derived mesenchymal stem cells (MSC) display impaired bone formation capacity in vivo. Lung-derived mesenchymal stem cells (MSC) display impaired.

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Lung-derived mesenchymal stem cells (MSC) display impaired bone formation capacity in vivo. Lung-derived mesenchymal stem cells (MSC) display impaired bone formation capacity in vivo. Cultured MSC derived from two lung-transplanted patients were subcutaneously transplanted (together with hydroxyapatite/tricalcium phosphate (HA/TCP) particles) into NOD/SCID mice. After 8 weeks, the transplants were removed, fixated and stained with H&E (A, B). Lung-derived MSC clearly formed adipocytes (a), stroma with invading haematopoietic cells (s) and an extracellular matrix (ECM). However, bone formation was hardly observable (*) compared with the bone formation (b) seen in the positive control (C, telomerase-immortalised human MSC). Arrow indicates a megakaryocyte. HA implants without cells served as negative controls (D). Scale bars indicate 100 μm. Sara Rolandsson et al. BMJ Open Resp Res 2014;1:e000027 ©2014 by British Thoracic Society