Selected host cell processes targeted by Dot/Icm effectors demonstrating the complexity of LCV biogenesis and maintenance as well as the broad range of.

Slides:

Advertisements

Similar presentations

Which of the following statements is the most correct? 1.Viral envelopes contain both viral and host proteins 2.Viral envelopes contain glycoproteins for.

Advertisements

Figure 2 Oestrogen receptor signalling pathways

Itraconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.

Replication of human astroviruses.

Functional range and environmental niches of the Pseudomonas genus, highlighting the broad distribution of the P. fluorescens species complex. Functional.

Schematic model of effector pathways that mediate tumor suppression by p53. Schematic model of effector pathways that mediate tumor suppression by p53.

Examples of immune response disruption by respiratory viruses.

(Left) Selected IgM immunoblot reactivities.

Pathogenic schemes of diarrheagenic E. coli.

A Phosphoinositide Code for Primary Cilia

RND efflux operons in P. aeruginosa.

Electron micrographs of the binding of human vitronectin to complement-resistant (left) and complement-sensitive (right) strains of M. catarrhalis. Electron.

Life cycle of HCMV in a human cell.

Approximate numbers of cases per 100,000 individuals caused by penicillin resistance for each year (left). Approximate numbers of cases per 100,000 individuals.

MexT-associated downregulation of oprD expression.

Mechanisms of drug actions during the viral life cycle.

Coregulation of mexEF-oprN and oprD in P. aeruginosa.

Fusion process between the RSV envelope and cellular membrane.

Pathways involved in regulation of macrophage iNOS synthesis and NO production in response to H. pylori. Pathways involved in regulation of macrophage.

Glucose concentration-dependent increase of melanin synthesis.

Binding and entry of RSV into the host cell.

Diagram of the group A streptococcal cell covered with an outer hyaluronic acid capsule and the group A carbohydrate, consisting of a polymer of rhamnose.

Structure of PrfA (A) and its target DNA sequences in PrfA-regulated promoters (B). Structure of PrfA (A) and its target DNA sequences in PrfA-regulated.

Positivity rates and concordance of multiplex PCR and blood culture (BC) results from 27 published studies. Positivity rates and concordance of multiplex.

Localization and cellular function of spectraplakins.

Fluconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.

Number of outbreaks associated with drinking water by water system type and year (n = 780), 1971 to “Other” includes outbreaks associated with bottled.

Percentages of outbreak deficiencies (n = 671) in public water systems (n = 656) by time period, 1971 to 2006, excluding outbreaks associated with Legionella.

Schematic representation of signaling by KSHV LANA

Schematic representation of signaling by EBV EBNA-2.

Schematic representation of signaling by high-risk human papillomavirus HPV E6. Schematic representation of signaling by high-risk human papillomavirus.

Mechanism of macrophage apoptosis caused by H. pylori.

A Rab-Centric Perspective of Bacterial Pathogen-Occupied Vacuoles

Schematic diagram of the JCV genome.

Drug transport mechanism of AcrB.

Number of outbreaks associated with drinking water by system type and month (n = 762), 1971 to 2006, excluding outbreaks associated with commercially bottled.

Summary of the distribution and genetic context of the OXA-type enzymes in Acinetobacter baumannii. Summary of the distribution and genetic context of.

Fabrizio Dutly, and Martin Altwegg Clin. Microbiol. Rev. 2001; doi:10

Dysregulation of the apical-junctional complex by H. pylori.

Staphylococcus aureus and Staphylococcus epidermidis cell surface proteins, known as microbial surface components recognizing adhesive matrix molecules.

Hector H. García et al. Clin. Microbiol. Rev. 2002; doi: /CMR

Physiological in vitro model for the study of host-microbiome interactions in BV. Transmission electron microscopy illustrates human vaginal epithelial.

Physiological effects of heat shock.

Publications on biosensors for the field in general compared with the specific detection of whole bacteria. Publications on biosensors for the field in.

Membrane-associated proteins expressed by human epithelial cells that function as receptors for Afa/Dr adhesins. Membrane-associated proteins expressed.

Schematic representation of the biogenesis of RV replication complexes

Roberta B. Carey et al. Clin. Microbiol. Rev. 2018; doi: /CMR

Forest plot of clinical trials reporting efficacy of acellular and whole-cell pertussis vaccines (38, 404, 590 – 593). Forest plot of clinical trials reporting.

Biogenesis of the Legionella-containing vacuole (LCV).

Schematic representation of 5′→3′ exonuclease cleavage of a 5′-labeled (small black star) probe with a 3′-phosphate (grey circle) extension blocker. Schematic.

Schematic description of sites of action of different antifungal agents. Schematic description of sites of action of different antifungal agents. Candins.

Stages of biofilm development (214).

Bacterial architecture and targets for biosensing.

The Scorpions primer is an extension of molecular beacons.

(A) T. vaginalis parasite as seen in broth culture.

Structure and function of RND efflux pumps in P. aeruginosa.

Phylogenetic trees for fusion (F) and attachment (G) genes of selected HMPV isolates. Phylogenetic trees for fusion (F) and attachment (G) genes of selected.

Pathogenesis of oncogenic HPV

The hantavirus life cycle.

Inhibitions of the proteasome and aggresome pathways by bortezomib and DACi. Unfolded and/or misfolded proteins are targeted by ubiquitin for degradation.

Reported events related to the replication cycle of Orientia tsutsugamushi in nonphagocytic cells. Reported events related to the replication cycle of.

Adherence patterns of enteropathogenic E

Host pattern recognition receptors involved in sensing S. pneumoniae.

Pathology of acute human Chagas' disease.

Putative molecular pathways showing how GSK3β regulates the fate of tumor cells (survival, proliferation, or apoptosis) and influences their sensitivity.

Cytokines and cytokine receptors involved in type I immunity in tuberculosis. Cytokines and cytokine receptors involved in type I immunity in tuberculosis.

Distribution of the four major molecular types of C

The T3SS apparatus consists of rings that provide a continuous path across the inner (IM) and outer (OM) bacterial membranes, including the peptidoglycan.

Schematic representation of the relationships between acid resistance (urease activity and urea transport), nitrogen metabolism (ammonia production), metal.

Amino acid substitutions in SHV ESBL derivatives.

Presentation transcript:

Selected host cell processes targeted by Dot/Icm effectors demonstrating the complexity of LCV biogenesis and maintenance as well as the broad range of effectors and pathways involved. Selected host cell processes targeted by Dot/Icm effectors demonstrating the complexity of LCV biogenesis and maintenance as well as the broad range of effectors and pathways involved. L. pneumophila effectors attack numerous cellular structures and host proteins; major targets include (clockwise from top left) host GTPases regulating vesicle trafficking, membrane phosphoinositides, host protein synthesis and stress response machinery, cell apoptosis, and host ubiquitination pathways. See the text for details. Larger circles represent ER-derived vesicles. Hayley J. Newton et al. Clin. Microbiol. Rev. 2010; doi:10.1128/CMR.00052-09