Schematic diagram of the recently described concept of “systems medicine” [93], which includes genetic characterisation, cell biology and physiology, imaging.

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Pathological changes in chronic obstructive pulmonary disease
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Schematic image of mast cell heterogeneity in a healthy human lung.
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Schematic diagram of the DETECT study [56].
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The natural history of chronic obstructive pulmonary disease (COPD) is a mixture of the natural history of the various phenotypes making up the umbrella.
Presentation transcript:

Schematic diagram of the recently described concept of “systems medicine” [93], which includes genetic characterisation, cell biology and physiology, imaging and analysis of clinical data and is a consistent, novel and interesting approach to unravel novel ... Schematic diagram of the recently described concept of “systems medicine” [93], which includes genetic characterisation, cell biology and physiology, imaging and analysis of clinical data and is a consistent, novel and interesting approach to unravel novel mechanisms in chronic respiratory disease (e.g. asthma and chronic obstructive pulmonary disease). Collection of these large amounts of data in cross-sectional and longitudinal studies and analysis using unbiased mathematical models may generate novel and unintuitive hypotheses. P-R. Burgel Eur Respir Rev 2011;20:023-033 ©2011 by European Respiratory Society