Tissue protection by erythropoietin: new findings in a moving field

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Tissue protection by erythropoietin: new findings in a moving field Masaomi Nangaku Kidney International Volume 84, Issue 3, Pages 427-429 (September 2013) DOI: 10.1038/ki.2013.140 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Cytoprotection by EPO. Endogenous kidney cells are protected by EPO. The beneficial effect is mediated by the tissue-protective receptor composed of EpoR and βcR. The canonical receptor of a homodimer of EpoR may also be involved in tissue protection. Klotho, another important factor produced by the kidney, increases expression of EpoR and enforces tissue protection. Kidney International 2013 84, 427-429DOI: (10.1038/ki.2013.140) Copyright © 2013 International Society of Nephrology Terms and Conditions