Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H or R1420C mutations. Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H.

Slides:

Advertisements

Similar presentations

Selective inhibition of BCL10-induced NF-κB activation by Tat–Peptide VIII HEK-293 cells were transiently co-transfected with an expression vector encoding.

Advertisements

C-Terminal Tails of Sulfonylurea Receptors Control ADP-Induced Activation and Diazoxide Modulation of ATP-Sensitive K+ Channels by Tetsuro Matsuoka, Kenji.

Yeast Tgl3p expressed in HeLa cells localizes to lipid droplets.

Enterotoxin A presence in lung AMs and dendritic cells.

MiR‐199a directly targets ERBB2 and ERBB3, whereas miR‐125b targets ERBB3. miR‐199a directly targets ERBB2 and ERBB3, whereas miR‐125b targets ERBB3. (A)

KLK7 is involved in the Aβ degradation activity

Volume 16, Issue 5, Pages (May 1996)

The fluorescent receptor chains exhibit their characteristic fluorescent signatures: images and spectra of human IFN-γR2/GFP and IFN-γR2/EBFP transfected.

Rapamycin inhibits TCR/CD3 engagement-dependent HIF-1α protein expression. Rapamycin inhibits TCR/CD3 engagement-dependent HIF-1α protein expression. Human.

A and B, CO-1686–resistant NCI-H1975 cell clones, COR1-1 and COR10-1 display a reduced dependence on EGFR signaling for survival. A and B, CO-1686–resistant.

Volume 57, Issue 3, Pages (March 2000)

Wild-type PC1 promotes ciliary localization of endogenous PC2 in ADPKD hepatoblasts. Wild-type PC1 promotes ciliary localization of endogenous PC2 in ADPKD.

Figure 2 DNM1 mutations inhibit transferrin uptake Inhibition of transferrin internalization in mammalian cell lines. DNM1 mutations inhibit transferrin.

ISS forming highly aggregated structures have decreased capability to induce maturation of human PDCs. Purified PDCs (105 cells) were stimulated with ISS.

NFAT5 is transcriptionally active in skeletal muscle cells in vitro.

mTORC1- and mTORC2-activating mutations in MTOR and RHEB

Decreased P-IR and total FOXO1 levels in an HFS diet.

Figure 4 DNM1 mutations affect protein levels and self-dimerization (A) HeLa cells were transfected with green fluorescent protein (GFP)-tagged mutant.

Effect of insulin on hepcidin expression in HepG2 cells.

Liver mitochondrial protein FSR

SCAP and SREBP-2 are important for synapse formation, nerve firing, and memory tasks. SCAP and SREBP-2 are important for synapse formation, nerve firing,

Volume 3, Issue 6, Pages (June 2006)

Ion channels expression and insulin secretion in the pancreatic islets of male offspring. Ion channels expression and insulin secretion in the pancreatic.

Expression of SENP2 mRNA is regulated by palmitate-induced NF-κB activation. Expression of SENP2 mRNA is regulated by palmitate-induced NF-κB activation.

Comparison of fluorescence spectra of cells expressing the FL-IFN-γR2/EBFP and FL-IFN-γR2/GFP chains in the presence and absence of the IFN-γR1 chain and.

Models of the mechanisms by which sulfonylureas and glucose control glucagon release. Models of the mechanisms by which sulfonylureas and glucose control.

MTORC1 regulates basal GLUT4 protein expression independent of VWR exercise. mTORC1 regulates basal GLUT4 protein expression independent of VWR exercise.

JAK3A572V mutation causes constitutive JAK3 activity and IL-2–independent proliferation of NKTCL cells. JAK3A572V mutation causes constitutive JAK3 activity.

IL-6 inhibits insulin-induced formation of p85/IRS-1 complexes.

IRS-1 and -2 expression in four mesangial cell lines from different D-NOD (A and B) and ND-NOD (C and D) mice. IRS-1 and -2 expression in four mesangial.

Multiple cis-acting elements in the IGRP promoter are required for maximal basal reporter gene expression in βTC-3 cells. βTC-3 cells were transiently.

A proximal region of the G6Pase catalytic subunit promoter is sufficient for maximal basal reporter gene expression in HIT cells. A proximal region of.

Linearity of the relationships between spectral abundance factors observed when 30 and 120 μg protein were analyzed, as described in research design and.

The effects of various fatty acids on the activity of the human ABCA1 promoter in RAW264.7 cells. The effects of various fatty acids on the activity of.

Type 2 diabetes status for R1420H carriers and noncarriers.

The prevalence of type 2 diabetes for R1420H carriers and noncarriers in relation to BMI. Diabetes prevalence is shown in individuals stratified by their.

Misfolding mutations impair the BRCA1 nuclear aggregation in yeast and the BRCA1 nuclear localization in human cells. Misfolding mutations impair the BRCA1.

VIP treatment decreased the number of apoptotic cells and increased cell proliferation. VIP treatment decreased the number of apoptotic cells and increased.

CPPED1 (A) and PPARγ2 (B) mRNA expressions in cultured SGBS cells during adipocyte differentiation. CPPED1 (A) and PPARγ2 (B) mRNA expressions in cultured.

The lack of effect of denatonium to stimulate insulin release in the absence of extracellular Ca2+ or in the presence of 10 μmol/l nitrendipine. The lack.

Ectopic expression of caveolin-1 in ZR75 human breast cancer cells downregulated survivin and decreased cell proliferation. Ectopic expression of caveolin-1.

Monitoring perturbation of ER-mitochondria interactions linked to genetic modulation of protein of the VDAC1/Grp75/IP3R1 complex by in situ PLA. Representative.

Exosome-mediated inhibition of T cells is reversible.

C/EBPα induces HSD1 expression and is a substrate of USP2–45.

Effect of high glucose and agents that alter mitochondrial metabolism on ROS production and expression of COX-2 mRNA in HMCs. Cells were incubated with.

Functional promoter activity of the human COX-2 gene in HMCs

LPL knockdown by RNAi in RC13 human rhabdomyosarcoma cell line.

SiRNA directed at Ngn1 inhibited differentiation of inner ear stem cells to β-III tubulin-positive cells. a, Inner ear stem cells treated with siRNA to.

Aβ-mediated Ras-MAPK signaling and Cyclin D1 expression in B103 cells are dependent on APP expression and can be reversed with MEK or Ras inhibition. Aβ-mediated.

Lipoprotein lipase is decreased in skeletal muscle of young, lean IR offspring of T2D parents. Lipoprotein lipase is decreased in skeletal muscle of young,

DPP-4 enhances M1 polarization and inhibits M2 polarization in macrophages in an ROS-dependent manner. DPP-4 enhances M1 polarization and inhibits M2 polarization.

Interaction between the G6PC2 rs G and rs G alleles on G6PC2 promoter activity. βTC-3 cells were transiently cotransfected, as described.

Gramicidin A (GA) decreases HIF protein expression in RCC cells.

Fig. 3 Hydrostatic pressure induces intracellular calcium increase via TRPM7 activation. Hydrostatic pressure induces intracellular calcium increase via.

Protein expression profile in a dasatinib-resistant cell line.

Proximal E-box sequence in Bdnf promoter 4 functions as a transcriptional suppressor. Proximal E-box sequence in Bdnf promoter 4 functions as a transcriptional.

Specific DNA methylation and expression signatures associated with binding of E2A–PBX1 fusion protein. Specific DNA methylation and expression signatures.

Expression of Her2 and drug efflux proteins in parental and resistant cell models. Expression of Her2 and drug efflux proteins in parental and resistant.

Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. Per1 inhibits growth and induces apoptosis in prostate cancer cell lines. LNCaP,

Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Expression.

Amino acid residues in the PD-L1 IgV domain involved in PD-1 and/or B7-1 binding. Amino acid residues in the PD-L1 IgV domain involved in PD-1 and/or B7-1.

Decreased dopamine uptake following downregulation of SLC6A3.

Double knockdown of HER2/EGFR abolishes HPSE nucleolar localization in 231BR3 cells. Double knockdown of HER2/EGFR abolishes HPSE nucleolar localization.

RPL26 is a positive regulator of TP53β splicing.

Expression of chemokine receptors in A-498 cell line.

NE cleaves and activates GSDMD.

HER2 and PI3K-targeted therapies result in FOXO3a-mediated feedback upregulation of HER3 and IGF1R and provide an escape from PI3K pathway inhibition.

MPD-L1–transfected 300 cells do not bind to mB7-1–transfected 300 cells. mPD-L1–transfected 300 cells do not bind to mB7-1–transfected 300 cells. Cell-to-cell.

ERM proteins promote CD44 cleavage.

Effect of SFN on the total activity and protein expression of HDACs in JB6 P+ cells. Effect of SFN on the total activity and protein expression of HDACs.

Presentation transcript:

Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H or R1420C mutations. Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H or R1420C mutations. Relative 86Rb+ efflux is shown as a function of time under basal conditions, in the presence of metabolic inhibition (MI), in the presence of KATP channel opener diazoxide, and for both control cells expressing green fluorescent protein and cells expressing R1420R, R1420H, or R1420C channels. Data are shown as mean ± SEM from four independent transfections. *P < 0.05, **P < 0.01 vs. R1420R for each case. Leslie J. Baier et al. Diabetes 2015;64:4322-4332 ©2015 by American Diabetes Association