A Targeted View Cell Volume 153, Issue 6, (June 2013)

Slides:

Advertisements

Similar presentations

Waging War on Cancer with the Sword of Immunity Cell Volume 158, Issue 2, (July 2014) DOI: /j.cell Copyright © 2014 Terms and Conditions.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

The Coming Peptide Tidal Wave

Inhibitor of MAP kinase activation blocks colon cancer growth

Virology Select Cell Volume 141, Issue 2, (April 2010)

Breaking Down Resistance

How IRE1 Reacts to ER Stress

Christopher J. Pirozzi, Zachary J. Reitman, Hai Yan Cancer Cell

Modeling Methuselah Cell Volume 154, Issue 1, (July 2013)

Genomics: Think Global, Act Local

Michael W.M. Kühn, Scott A. Armstrong Cancer Cell

C2 Can Do It, Too Cell Volume 121, Issue 2, Pages (April 2005)

Chromatin Organization

Michael W.M. Kühn, Scott A. Armstrong Cancer Cell

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses

Cardiac Damage and Its Repair

Neurobiology Select Cell Volume 129, Issue 2, (April 2007)

Volume 148, Issue 3, (February 2012)

In This Issue Cell Volume 158, Issue 5, (August 2014)

Miquel Duran-Frigola, Roberto Mosca, Patrick Aloy Chemistry & Biology

Select: The Many Faces of Cancer

Volume 136, Issue 1, (January 2009)

Volume 131, Issue 7, (December 2007)

Resurrection Cell Volume 162, Issue 2, (July 2015)

Rab5 and Rac Team Up in Cell Motility

Volume 143, Issue 5, (November 2010)

Control of Biomolecule Abundance

Volume 173, Issue 4, Pages (May 2018)

Rewriting the Epigenome

Volume 152, Issue 1, (January 2013)

Targeting Disease through Metabolism

Volume 127, Issue 1, (October 2006)

Select: Manipulating Cellular Machinery

Volume 139, Issue 5, (November 2009)

Prion Progress Cell Volume 153, Issue 3, (April 2013)

Volume 130, Issue 6, (September 2007)

Better Imaging through Chemistry

Volume 130, Issue 6, (September 2007)

Biological Code Breaking

A Place and a Grid in the Sun

AKT/PKB Signaling: Navigating Downstream

Tetherin Is as Tetherin Does

Brother’s Keeper: Wild-Type Mutant K-Ras Dimers Limit Oncogenesis

Volume 143, Issue 6, (December 2010)

Volume 143, Issue 3, (October 2010)

Bumping Up Kinase Activity with an ATP-Derived Neo-Substrate

Volume 166, Issue 4, Pages (August 2016)

Structural Biology Select

Ebolavirus’s Foibles Cell

Making the Most from Changes in Life

Autophagy SEPArates Germline and Somatic Cells

The Long Tail of mRNA Regulation

Bispecific Antibodies Against HIV

Insider Influence on ErbB Activity

Egg's ZP3 Structure Speaks Volumes

Learning from the Uncontrollable

The Structure of Host-Pathogen Interactions

Shared Principles in NF-κB Signaling

Table of Contents Nurse Leader Volume 16, Issue 3, (June 2018)

Delivering Three Punches to Knockout Intracellular Bacteria

Propofol: Milk of Amnesia

Volume 163, Issue 4, (November 2015)

Volume 163, Issue 2, (October 2015)

Volume 134, Issue 6, (September 2008)

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Recalculating… Cell Volume 160, Issue 6, (March 2015)

Presentation transcript:

A Targeted View Cell Volume 153, Issue 6, (June 2013) Cell Volume 153, Issue 6, (June 2013) DOI: 10.1016/j.cell.2013.05.032 Copyright © 2013 Terms and Conditions

The mTOR FRB domain (red) restricts access to the kinase domain (pink) and has a dual substrate recruitment/rapamycin-binding site (green). Image courtesy of N. Pavletich. Cell 2013 153, DOI: (10.1016/j.cell.2013.05.032) Copyright © 2013 Terms and Conditions

Structure of the human smoothened receptor, critical in embryonic development. Image generated by Katya Kadyshevskaya, Stevens Laboratory, TSRI. Cell 2013 153, DOI: (10.1016/j.cell.2013.05.032) Copyright © 2013 Terms and Conditions

X-ray structure of the potent and selective inhibitor WEHI-539 bound to the canonical hydrophobic groove of BCL-XL. Image courtesy of G. Lessene and P. Czabotar. Cell 2013 153, DOI: (10.1016/j.cell.2013.05.032) Copyright © 2013 Terms and Conditions

A molecule of AGI-6780 binds at the dimer interface of mutant IDH2 (R140Q). Image courtesy of Eric D. Smith. Cell 2013 153, DOI: (10.1016/j.cell.2013.05.032) Copyright © 2013 Terms and Conditions