ChREBPα increases β-cell mitochondrial activity and ATP production in human islets. ChREBPα increases β-cell mitochondrial activity and ATP production.

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ChREBPα increases β-cell mitochondrial activity and ATP production in human islets. ChREBPα increases β-cell mitochondrial activity and ATP production in human islets. A: Dispersed human islets were transduced with the indicated adenovirus, treated as shown, and labeled with MitoTracker Red CMXRos (Mito) and an anti-insulin antibody (ins). Scale bars = 20 μm. B: The mitochondrial signal intensity was determined from the images in A and is shown relative to the control (treated with low glucose [Glu]). C: Total intracellular ATP content was determined in human islets and normalized to protein content. Data are shown as a percentage of the control (stimulated with low Glu and treated with Ad.LacZ). The values shown are the mean ± SE (n = 3–5). *P < 0.05, **P < 0.01. MFI, mean fluorescence intensity. Anil Kumar et al. Diabetes 2018;67:1561-1575 ©2018 by American Diabetes Association