Caloric intake in lean and obese Zucker rats in response to systemic infusion of glucose alone (HG-HI protocol) or glucose with insulin (EuG-HI protocol).

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Caloric intake in lean and obese Zucker rats in response to systemic infusion of glucose alone (HG-HI protocol) or glucose with insulin (EuG-HI protocol). Caloric intake in lean and obese Zucker rats in response to systemic infusion of glucose alone (HG-HI protocol) or glucose with insulin (EuG-HI protocol). Daily food intake was measured between 9:00 and 10:00 a.m. before starting the infusion to determine basal caloric intake for each rat (0) and again after 24 and 48 h of infusion, as indicated. Variable amounts of glucose were infused, depending on the infusion protocol and genotype. The caloric intake from food (▪) was calculated on the basis of 3 kcal/g of pellet. The calories supplied by glucose (□) were calculated according to infusion rates, given that the 30% wt/vol solution of glucose infused provides 1.2 cal/μl. Both bars are added to display the total caloric intake during infusion. Data are means ± SE for nine (HG-HI) and six (EuG-HI) rats of each genotype. *P < 0.01 vs. lean by unpaired t test; †P < 0.01 vs. basal caloric intake by paired t test. Marc Gilbert et al. Diabetes 2003;52:277-282 ©2003 by American Diabetes Association