SENP2 overexpression increases FAO by upregulating expression of FAO-associated enzymes in muscle. SENP2 overexpression increases FAO by upregulating expression.

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SENP2 overexpression increases FAO by upregulating expression of FAO-associated enzymes in muscle. SENP2 overexpression increases FAO by upregulating expression of FAO-associated enzymes in muscle. A–C: WT and mSENP2-TG (TG) mice were fed with chow or HFD for 12 weeks. The levels of free fatty acids (FFA) (A), triglycerides (B), and FAO (C) in their gastrocnemius muscle were determined (n = 8/group). D and E: Total mRNAs were isolated from the muscles of the mice and subjected to real-time PCR (n = 10–14/group) using primers for FAO-associated enzymes (D) and PPARs and PGC1α (E). The mRNA level seen in chow-fed WT mice muscle was expressed as 1.0, and the others were expressed as its relative values. Data are the mean ± SEM. *P < 0.05 compared with WT mice. Young Do Koo et al. Diabetes 2015;64:2420-2431 ©2015 by American Diabetes Association