Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning. Phosphorylated CREB levels were assessed.

Slides:

Advertisements

Similar presentations

FMRP suppresses dendritic Arc protein levels.

Advertisements

From: Propofol Limits Microglial Activation after Experimental Brain Trauma through Inhibition of Nicotinamide Adenine Dinucleotide Phosphate Oxidase Anesthes.

From: Protective Effect of a GLP-1 Analog on Ischemia-Reperfusion Induced Blood–Retinal Barrier Breakdown and Inflammation Invest. Ophthalmol. Vis. Sci..

Supplementary Figure 1. Deficits in cognitive function persist up to 11 wks post-injury in moderate-level CCI TBI mice. Sham-injured and CCI TBI mice.

Pioglitazone treatment prevents TRPC6 overexpression and podocyte injury in the adriamycin (ADRIA)–induced nephropathy rat model for FSGS. ADRIA-induced.

Sildenafil does not prevent TRPC6 overexpression and podocyte injury in adriamycin (ADRIA)–challenged podocyte-specific PPAR-γ KO mice. Sildenafil does.

DH E2 infusion significantly increased phosphorylation of the p42 isoform of ERK (A) and of Akt (B) in the DH of OVX females, but not sham GDX males. DH.

AβOs induce hypothalamic inflammation, eIF2α phosphorylation and impaired insulin signaling A, BWestern blot analysis of eIF2α‐P levels in the hypothalamus.

Fig. 3 Biological function of TG2 and the interaction with MT-2.

Adult (2- to 4-mo-old) Nlgn3y/– mice modify the social behavior of their littermates. Adult (2- to 4-mo-old) Nlgn3y/– mice modify the social behavior of.

SNI causes a reduction in AIS length in the IL, an effect that is partially reversed by metformin. SNI causes a reduction in AIS length in the IL, an effect.

Nikole J. Byrne et al. BTS 2017;j.jacbts

Fig. 4. Perampanel ameliorates behavioral deficits in mice expressing the Thorase variants. Perampanel ameliorates behavioral deficits in mice expressing.

Improvement of insulin sensitivity by treatment of the annexin A1 receptor agonist in HFD mice. Improvement of insulin sensitivity by treatment of the.

Farah D. Lubin, J. David Sweatt Neuron

TRPV1 mediates Ca2+ flux and cytoskeletal fragmentation during trophic factor deprivation. TRPV1 mediates Ca2+ flux and cytoskeletal fragmentation during.

Volume 53, Issue 5, Pages (March 2007)

Effects of E2 on levels of phospho-CREB in the DH of OVX females, sham males, and GDX males. Effects of E2 on levels of phospho-CREB in the DH of OVX females,

DFP-induced astrogliosis is reduced by urethane.

Reduced phosphorylation of IKKα/β, p65 and delayed IκBα degradation and reduced NF-κB activation in bid−/− microglia. Reduced phosphorylation of IKKα/β,

Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses Pei-Yi Lin, Ege T. Kavalali, Lisa M.

Reversal of MOR lysosomal targeting by silencing enhanced Rab7 expression. Reversal of MOR lysosomal targeting by silencing enhanced Rab7 expression. A:

TOR, but not OSP, blocks STx2B transport and alters endosomal dynamics

CK2 phosphorylates mammalian FMRP S499.

AAS-dependent induction of autophagic flux in ARPE-19.

Presynaptic OSN GABA receptors accelerate behavioral responses to odor pulse termination. Presynaptic OSN GABA receptors accelerate behavioral responses.

Results of CFC training and testing.

APT1 palmitoylation and localization.

Increased phosphorylation of Akt, Girdin S1416, and NR2B of NMDA receptor in the hippocampus of mouse after fear conditioning. Increased phosphorylation.

Peli1 levels are reduced in bid−/− microglia upon LPS stimulation.

Arterial and portal plasma glucagon levels and the portal-arterial (P-A) glucagon gradient in the control period (−40 to 0 min) and after administration.

The portal-arterial (P-A) insulin gradient and arterial plasma c-peptide levels in the control period (−40 to 0 min) and after administration of the glycogen.

Diclofenac treatment reduces L-selectin on peripheral blood and infiltrated leukocytes but does not alter accumulation in the injured spinal cord. Diclofenac.

Loss of ATF3 function modestly reduces axonal regeneration following sciatic nerve crush. Loss of ATF3 function modestly reduces axonal regeneration following.

Intraperitoneal injection of tBHQ reduced sensorimotor deficit and stroke damage 24 h after ischemia-reperfusion. Intraperitoneal injection of tBHQ reduced.

Fig. 3 Biological function of TG2 and the interaction with MT-2.

Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation and fear conditioning. Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation.

Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. BMMs.

Chronic SSRI treatment rescued lOFC hyperactivity in QNP-treated mice.

MSK1 is necessary for BDNF-dependent CREB phosphorylation in area CA1.

Gene delivery of ChABC leads to improved sensorimotor function and spinal conduction following spinal contusion. Gene delivery of ChABC leads to improved.

Interference of Kv4 in dorsal neurons (DN1s) does not significantly regulate sleep onset. Interference of Kv4 in dorsal neurons (DN1s) does not significantly.

Disrupted Ca2+ homeostasis enhances wild-type TDP-43 toxicity.

Transgenic expression of mCREB or CREB produces opposite effects in the learned helplessness model of depression. Transgenic expression of mCREB or CREB.

Peripheral surgery regulates expression of astrocytic markers.

The developmental spine morphology changes predict decreased biochemical compartmentalization with age, while loss of FMRP subtly influences this in an.

Western blotting for GluR1.

TBS- and HFS activate different signaling pathways.

A, Elevation in the amount of solution consumed (without sucrose or salt) during the depletion test following sodium depletion compared with the baseline.

Minocycline treatment inhibited dorsal column transection-induced glial cell death within the distal and proximal AST. A, Percentage of apoptotic microglia/macrophages.

Distribution of NE- and KCl-responsive precursor cells along the septotemporal axis of the hippocampus. Distribution of NE- and KCl-responsive precursor.

NPC-derived oligodendrocytes are maintained long term after cuprizone challenge. NPC-derived oligodendrocytes are maintained long term after cuprizone.

MET-1 increases DRG neuron K+ currents.

FMRP S499 rephosphorylation kinetics after CX-4945 treatment and washout mirrors a known CK2 target. FMRP S499 rephosphorylation kinetics after CX-4945.

CPARs in the NAc protect against depression-like behaviors induced by chronic pain. CPARs in the NAc protect against depression-like behaviors induced.

Gld2 and Ngd regulate glycine-induced GluN2A synthesis and surface expression in dendrites. Gld2 and Ngd regulate glycine-induced GluN2A synthesis and.

Intra-amygdala MPEP is analgesic during bladder distention.

FMRP S499 is phosphorylated by multiple kinases in vitro.

Cytokine expression in the ileum and colon.

Effects of receptor antagonists, Ca2+ channel blocker, Ca2+depletion, and protein kinase inhibitors on CREB phosphorylation in cultured hippocampal neurons.

Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion. Effects of CNO on spontaneous locomotion and amphetamine-induced hyperlocomotion.

At P23, dendritic spine density on L2/3 pyramidal cells in PirB−/− visual cortex is similar to that of PirB+/+. At P23, dendritic spine density on L2/3.

Optogenetically stimulated Aβ fibers induce pain-like behaviors after PNI. A, B, Withdrawal score by light (A) and paw withdrawal threshold by von Frey.

Induction of liver NQO1 activity in juvenile female rats treated for 3 d (10 mg/kg qd SERMs or 0.1 mg/kg qd E2 or vehicle control). Induction of liver.

Fig. 7 FAE-20 increases hippocampal excitability and leads to more stable contextual fear memory in mice. FAE-20 increases hippocampal excitability and.

Impact of eNOS expression and treatment with GSNO on prostate tumor growth. Impact of eNOS expression and treatment with GSNO on prostate tumor growth.

Increased spike ADP in pilocarpine-treated rats is sensitive to spermine. Increased spike ADP in pilocarpine-treated rats is sensitive to spermine. A,

Subodh Verma et al. BTS 2018;3:

Effects of rapamycin, cycloheximide, and an MAP kinase inhibitor (U0126) on BDNF-mediated increase in Arc and CaMKII in acute hippocampal slices. Effects.

Bid associates with TRAF6 in microglia and astrocytes, as shown by coimmunoprecipitation and PLA. A, Coimmunoprecipitation of Bid and TRAF6 in BV-2 cells.

Presentation transcript:

Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning. Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning. A, Representative Western blots. B, Densitometric analysis. CREB phosphorylation significantly increased in sham animals after training, but not in TBI animals treated with vehicle 30 min before training (n = 6/group). Rolipram rescued the TBI-induced deficits in CREB phosphorylation after learning. *p < 0.05 versus untrained sham + vehicle animals, **p < 0.01 versus untrained sham + vehicle animals, (one-way ANOVA with Bonferroni's post hoc comparison). #p < 0.01 for TBI + vehicle versus TBI + rolipram animals (one-way ANOVA with Bonferroni's post hoc comparison). David J. Titus et al. J. Neurosci. 2013;33:5216-5226 ©2013 by Society for Neuroscience