Electrically evoked dopamine transients and regulation of dopamine signals by firing frequency in wild-type and triple-synuclein-null mutant mice measured.

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Electrically evoked dopamine transients and regulation of dopamine signals by firing frequency in wild-type and triple-synuclein-null mutant mice measured by FCV. A, Mean profiles of [DA]o versus time (mean ± SEM) after a single pulse (0.2 μs; arrow) in the... Electrically evoked dopamine transients and regulation of dopamine signals by firing frequency in wild-type and triple-synuclein-null mutant mice measured by FCV. A, Mean profiles of [DA]o versus time (mean ± SEM) after a single pulse (0.2 μs; arrow) in the dorsal striatum (CPu). In CPu, peak [DA]o transiently evoked by single pulses is greater in triple-synuclein-null mutant (α−/−β−/−γ−/−) than wild-type (WT) mice [***p < 0.001, one-way ANOVA; WT, n = 81; α−/−β−/−γ−/−, n = 86 (5 animals for each genotype)]. B, Histogram of peak [DA]o of evoked dopamine transients in the CPu in wild-type versus triple-synuclein-null mutant mice for individual sampling sites. C, Mean peak [DA]o ± SEM versus frequency during five-pulse trains (1–100 Hz) in the CPu in both genotypes (p > 0.05, two-way ANOVA; 3 animals per genotype,). D, Mean profiles of [DA]o versus time (mean ± SEM) after a single pulse (arrow) in the ventral striatum (NAc). There is no significant difference between genotype in peak evoked [DA]o [p > 0.05, one-way ANOVA; n = 26 for both genotypes (4 animals per genotype)]. E, F, Dopamine concentrations (nanograms per milligram of protein) in the CPu and NAc dissected from the striatal slices were normalized to the mean value for wild-type animals in each brain structure (100%). Means ± SEM of data obtained from 8 wild-type (WT) and 11 triple-synuclein-null mutant (α−/−β−/−γ−/−) mouse samples are shown (*p < 0.05; Kolmogorov–Smirnov test). Sabina Anwar et al. J. Neurosci. 2011;31:7264-7274 ©2011 by Society for Neuroscience