Preterm birth reduces the incidence of atopy in adulthood

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Presentation transcript:

Preterm birth reduces the incidence of atopy in adulthood Mirjami Siltanen, MD, PhD, Karoliina Wehkalampi, MD, PhD, Petteri Hovi, MD, Johan G. Eriksson, MD, PhD, Sonja Strang-Karlsson, MD, Anna-Liisa Järvenpää, MD, PhD, Sture Andersson, MD, PhD, Eero Kajantie, MD, PhD Journal of Allergy and Clinical Immunology Volume 127, Issue 4, Pages 935-942 (April 2011) DOI: 10.1016/j.jaci.2010.12.1107 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Percentages of study participants grouped by gestational age at birth who had at least 1 positive skin prick test reaction. Within the very-low-birth-weight (VLBW) group (gestational age at birth <37 weeks), reduction of gestational age by 1 week was associated with a lower risk of atopy based on skin prick test results (adjusted OR, 0.82; 95% CI, 0.68-0.98). Journal of Allergy and Clinical Immunology 2011 127, 935-942DOI: (10.1016/j.jaci.2010.12.1107) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Percentages of study participants grouped by gestational age at birth with high concentrations (>0.8 kU/L) of at least 1 serum allergen-specific IgE. Within the very-low-birth-weight (VLBW) group (gestational age at birth <37 weeks), a 1-week reduction in gestational age was associated with a lower risk of high concentrations of allergen-specific IgE (adjusted OR, 0.82; 95% CI, 0.68-0.99). Journal of Allergy and Clinical Immunology 2011 127, 935-942DOI: (10.1016/j.jaci.2010.12.1107) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions