Half-life of removal from subcutaneous administration site after subcutaneous administration of fluorescence-labeled VEGF-C156S, ovalbumin (OVA), bovine.

Slides:

Advertisements

Similar presentations

Representative 10-s EEG recordings from GAERS: during baseline (prior to injection of any drug) (i), following the i.c.v. injection of 4 μl of vehicle.

Advertisements

Plasma insulin concentrations (A) and insulin secretion rates (B) in response to molar increments of plasma glucose concentration during the graded glucose.

Dose-response relationships. A

Htr-9 stimulates ICAM-1 gene expression in human ASM cells.

Checklist for Site Reconnaissance (Sabatini et al_2002)

Comparison of the model incorporating daily dose to that incorporating Cmax. Comparison of the model incorporating daily dose to that incorporating Cmax.

Effects of cytokines on P450 mRNA expression in human hepatocytes.

Evaluation of models incorporating the base covariates.

Volume 18, Issue 2, Pages (February 2010)

by Petri Salven, Lasse Teerenhovi, and Heikki Joensuu

The context-sensitive half-times for commonly used intravenous anesthetic drugs. [Reproduced from Reves JG, Glass PSA, Lubarsky DA, McEvoy MD, and Martinez-Ruiz.

IL-21 Reduces Immediate Hypersensitivity Reactions in Mouse Skin by Suppressing Mast Cell Activation or IgE Production Risa Tamagawa-Mineoka, Tsunao.

Representative radio-HPLC chromatograms for individual pooled methanolic fecal extracts for periods of maximum recovery of radioactivity after dosing of.

HPLC tracings of resveratrol (RV) and its major sulfate conjugates M4/M5 in the plasma from three subjects. HPLC tracings of resveratrol (RV) and its major.

Figure 10. Recovery of the acetyl-CoA and ATP levels by glucose administration. Figure 10. Recovery of the acetyl-CoA and ATP levels by glucose administration.

Total ion current-EMS chromatograms of SB939 and its metabolites after incubation in liver microsomal fractions for 60 min at a concentration of 50 μM.

Structure of solid lipid nanoparticles (SLNs).

The three primary ADC components that determine which cells are targeted (antibody), how the drug is released (linker/trigger), and the mechanism of action.

Label Name Label Name Label Name Label Name Label Name Label Name

T-type calcium channel regulators.

VEGF signals via a paracrine loop to VEGFR-2 in the glomerulus.

Mechanisms of H2S release from S-aroylthiooximes (SATOs).

Model B. The melatonin-produced increase in extracellular dopamine concentration in the striatum is prevented by the CYP2D inhibitor propafenone in pargyline-pretreated.

Cytotoxic activities of polymer micelles containing CFZ in H460 (A) and select micelle formulations in RPMI-8226 (B) cell lines. Cytotoxic activities of.

Cytotoxic effects of PM1 and PM2 empty particle controls and coincubation of CFZ with empty particles tested in H460 (A) and RPMI-8226 (B) cells. Cytotoxic.

Geometric mean concentration-time profiles of (A) racemic BUP, R-BUP, and S-BUP; (B) racemic OHBUP, RR-OHBUP, and SS-OHBUP; (C) racemic ERY, SR-ERYHBUP,

The additive model assumes unspecific effects of equal size in both the placebo and drug arm or groups of studies or experiments. The additive model assumes.

Fluorescence-based in vivo imaging of MSP.

Effects of inhibitors of drug efflux pumps on the penetration of antibiotics into the central nervous system. Effects of inhibitors of drug efflux pumps.

Comparison of the observed and calculated CLR values of taurine and GCDCA-S. Comparison of the observed and calculated CLR values of taurine and GCDCA-S.

(A) Illustration depicting two types of pharmacokinetic instability of an ADC. Conjugating an antibody with drug can accelerate its clearance (green versus.

Validation of select PDN drug candidates in an in vivo endotoxemia model Validation of select PDN drug candidates in an in vivo endotoxemia model Therapeutic.

Effects of gemfibrozil on the exposure (area under the plasma drug concentration-time curve) to different CYP2C8 substrate drugs. Effects of gemfibrozil.

Schematic illustration of the interaction between CYP2C8 and its glucuronide substrates. Schematic illustration of the interaction between CYP2C8 and its.

Results of thermogravimetric measurements of peptide ghrelin antagonist (GhA) and loaded into PSi microparticles. Results of thermogravimetric measurements.

Effects of insulin administration in streptozotocin-treated mice.

(A) Mean (SD) serum continuous erythropoietin receptor activator (C. E

Dose-normalized plasma concentration-time curves of a mAb following subcutaneous (SC) and intravenous (IV) administration to cynomolgus monkeys (mean ±

A1C (A) and serum glycated albumin (GA) (B) levels in 47 pregnant women (study 1) divided according to gestational period into group I (21–24 weeks; n.

Fraction of dose (mean, n = 3–4) recovered in peripheral lymph following subcutaneous administration to sheep for a series of small molecular compounds.

Stereoimage of three independent docking simulations of the interaction between clopidogrel acyl 1-β-d-glucuronide and the active site of CYP2C8. Stereoimage.

Colonization in tumor models and different modes of administration

Immunohistochemistry for peripheral blood-born macrophage infiltration

A loading dose decreases the time to achieve the target concentration.

Damage-associated molecular pattern (DAMP)-induced activation of Toll-like receptors (TLRs). Damage-associated molecular pattern (DAMP)-induced activation.

CBD elevates AEA levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. CBD elevates AEA levels in poly-(I:C)–stimulated HaCaT cells after 6 hours.

Schematic diagram illustrating a theoretical model of amygdala modulation of memory and synaptic plasticity in the hippocampus. Schematic diagram illustrating.

Bovine-Serum-Albumin-Containing Receptor Phase Better Predicts Transdermal Absorption Parameters for Lipophilic Compounds Sheree E. Cross, Yuri G. Anissimov,

CBD and other phytocannabinoids are not cytotoxic in HaCaT cells.

The CYP2C8 gene is located to the CYP2C gene cluster on chromosome 10.

Uptake of diazepam (1 μM; A and E), pitavastatin (1 μM; B and F), rosuvastatin (1 μM; C and G), and pravastatin (1 μM; D and H) by human hepatocytes measured.

Uptake of TPP+ by human hepatocytes measured after incubation at 37°C (circles) or on ice (triangles) for 0.5–60 minutes. Uptake of TPP+ by human hepatocytes.

Unbound drug concentrations in plasma (dotted) and brain ISF (solid, calculated from recovery and dialysate concentration) following repeated subcutaneous.

AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels.

Activation and desensitization of the α7 nAChRs.

Fig. 1 OVA-releasing scaffolds concentrate OVA-specific CD4+T cells following ischemic injury. OVA-releasing scaffolds concentrate OVA-specific CD4+T cells.

The effect of a change in the expression level of the receptor and the binding affinity on the subcutaneous bioavailability of mAbs. The effect of a change.

Neighbor joining tree showing relationships between the human cannabinoid CB1 and CB2 receptors and other human rhodopsin α-group type G protein-coupled.

Mean serum concentration time profiles of anifrolumab following subcutaneous and intravenous administration of anifrolumab.a aData below the limits of.

Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R mg/kg (n.

Average trastuzumab serum concentrations in female minipigs following single subcutaneous administration of trastuzumab in formulations without and with.

Effect of bevacizumab on the proliferation of A2780 cells.

Allometric relationship between the lymph flow in the thoracic duct and species body weight. Allometric relationship between the lymph flow in the thoracic.

Immune response of CEA-transgenic mice transferred with OT-1 splenocytes and immunized with ovalbumin and adjuvant. Immune response of CEA-transgenic mice.

Cy5.5-labeled anti-B7-H4 BsAb (Fab-scFv) localization in tumor-bearing mice and BsAb half-life in mouse blood. Cy5.5-labeled anti-B7-H4 BsAb (Fab-scFv)

Volume 18, Issue 2, Pages (February 2010)

Plasma concentration-time profile after oral administration of a single dose. Plasma concentration-time profile after oral administration of a single dose.

Relationship between darunavir IQ and the probability of virologic success (HIV-1 RNA

(A) Percentage of patients achieving remission or response at week 12 or 24 after initiating ova therapy. (A) Percentage of patients achieving remission.

Fig. 4 PPM-DD–optimized ND-drug combinations.

Presentation transcript:

Half-life of removal from subcutaneous administration site after subcutaneous administration of fluorescence-labeled VEGF-C156S, ovalbumin (OVA), bovine serum albumin (BSA), and bevacizumab in mice (data from Wu et al., 2012). Half-life of removal from subcutaneous administration site after subcutaneous administration of fluorescence-labeled VEGF-C156S, ovalbumin (OVA), bovine serum albumin (BSA), and bevacizumab in mice (data from Wu et al., 2012). Wolfgang F. Richter, and Björn Jacobsen Drug Metab Dispos 2014;42:1881-1889 Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics