Fig. 3 IT1t blocks TLR7-mediated IFN production of circulating pDCs in PBMC cultures. IT1t blocks TLR7-mediated IFN production of circulating pDCs in PBMC.

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Fig. 3 IT1t blocks TLR7-mediated IFN production of circulating pDCs in PBMC cultures. IT1t blocks TLR7-mediated IFN production of circulating pDCs in PBMC cultures. (A and B) PBMCs from healthy individuals were cultured with R848 (5 μg/ml). IFN-producing cells were identified by flow cytometry. (C) Percentage of pDCs within the IFN-α+ PBMCs after R848 stimulation from six different donors. (D) Individual and (E) combined representation of the effects of AMD3100 and IT1t on R848-induced IFN-α production in the pDC fraction from PBMCs from four healthy donors. Box and whisker plots with median ± minimum to maximum. Friedman test with Dunn’s post hoc correction. “*” represents the statistical analysis comparing IT1t to the control R848 alone. “X” represents the statistical analysis comparing each concentration of IT1t to AMD3100. **P < 0.01, *P < 0.05. NS, nonstimulated. Nikaïa Smith et al. Sci Adv 2019;5:eaav9019 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).