Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.

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Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin. Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin. (A) Representative flow cytometric analysis of CD45RA and CLA expression by live gated CD4+ T cells from blood and skin of healthy donors. (B) Representative flow cytometric analysis of CCR7 and CD103 expression by live gated CD4+CD45RA−CLA+ memory T cells from blood and skin of healthy donors. (C) Graphical summary of the proportions of CCR7- and CD103-defined T cell populations among CD4+CD45RA−CLA+ T cells from blood and skin. (D and E) Representative flow cytometric analysis and graphical summary of expression of the indicated markers by CD4+ T cell populations in the blood and skin as indicated. Significance was determined by one-way repeated-measures ANOVA with Tukey’s posttest for pairwise comparisons. Maria M. Klicznik et al. Sci. Immunol. 2019;4:eaav8995 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works