Major hematopoietic cell populations in NOD mice are not affected by c-Rel deficiency. Major hematopoietic cell populations in NOD mice are not affected.

Slides:

Advertisements

Similar presentations

c-Myc expression in response to pre-TCR stimulation.

Advertisements

Figure 2. Positive selection of J15 TCR transgenic T cells specific for H60. (A) CD4 by CD8 profiles (left) of thymocytes and numbers (right) of each thymic.

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development by Eva Eckelhart, Wolfgang Warsch, Eva Zebedin, Olivia.

by Jad I. Belle, David Langlais, Jessica C

B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition. B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition.

by Dior Kingston, Michael A

IL-21 induces the expression of CX3CL1 in the muscle in EAM

Volume 13, Issue 2, Pages (August 2013)

Depletion of CD169+ cells leads to increased expression of CD25 on enterotoxin A–specific Vβ3+ T cells. Depletion of CD169+ cells leads to increased expression.

Attenuated MDSC-suppressive activity and metastasis development in IDO-deficient mice is rescued by IL-6. Attenuated MDSC-suppressive activity and metastasis.

Volume 18, Issue 1, Pages (January 2017)

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis by Stanley C. W. Lee, Sarah Miller, Craig.

Volume 142, Issue 2, Pages e2 (February 2012)

Volume 19, Issue 6, Pages (December 2003)

Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors by Krista M. Heinonen, Juan Ruiz Vanegas,

by Ute Koch, Anne Wilson, Monica Cobas, Rolf Kemler, H

Volume 9, Issue 4, Pages (October 1998)

Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models by Paola Rivera-Munoz, Anouchka P. Laurent,

Volume 41, Issue 2, Pages (August 2014)

Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice by Julie Lang, Bicheng Zhang, Margot Kelly, Jacob.

Increased chemokine content and leukocyte infiltrate in D6-negative tumors. Increased chemokine content and leukocyte infiltrate in D6-negative tumors.

Volume 23, Issue 1, Pages (April 2018)

CD160−/− IELs have a defect in granzyme B production during L

Volume 7, Issue 4, Pages (October 1997)

Acquisition of a Functional T Cell Receptor during T Lymphocyte Development Is Enforced by HEB and E2A Transcription Factors Mary Elizabeth Jones, Yuan.

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

Volume 10, Issue 5, Pages (November 2004)

Volume 29, Issue 1, Pages (July 2008)

SHIP is required for a functional hematopoietic stem cell niche

Volume 36, Issue 3, Pages (March 2012)

Volume 6, Issue 6, Pages (June 1997)

Saskia Hemmers, Alexander Y. Rudensky Cell Reports

Immune cell populations, activation, and NKG2D and H60a expression in the spleen of untreated and antibiotic-treated Klrk1+/+ and Klrk1−/− NOD mice. Immune.

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

Homeostasis of dendritic cells in lymphoid organs is controlled by regulation of their precursors via a feedback loop by Kristin Hochweller, Tewfik Miloud,

Volume 24, Issue 1, Pages (January 2006)

STAT3 Is Required for Flt3L-Dependent Dendritic Cell Differentiation

Volume 32, Issue 3, Pages (March 2010)

Volume 21, Issue 1, Pages (October 2017)

Volume 7, Issue 1, Pages (July 1997)

Volume 41, Issue 4, Pages (October 2014)

SAP Protein-Dependent Natural Killer T-like Cells Regulate the Development of CD8+ T Cells with Innate Lymphocyte Characteristics Mihalis Verykokakis,

Development of human T-cell subsets in NSG hL-7xhIL-15 humanized mice.

The 3′F allele does not recapitulate the systemic hyperimmune phenotypes associated with mir-146a deficiency. The 3′F allele does not recapitulate the.

cMΦ develop into 4 subpopulations after birth.

The mucosal environment regulates CD160 expression on IELs

Increased reconstitution of human NK cells in NSG hIL-7xhIL-15 humanized mice. Increased reconstitution of human NK cells in NSG hIL-7xhIL-15 humanized.

Analysis of peripheral blood CD4+CD25+ T-cells after B6

GPR55 restrains IEL accumulation in the small intestine.

TSG-6 suppressed APC activation in vitro and in vivo.

Volume 21, Issue 1, Pages (October 2017)

B cell development in wild-type and Syk-AQL mice.

Volume 9, Issue 3, Pages (September 1998)

Phenotypic characterization of splenic and islet-infiltrating B-cells in 12-week-old NOD female mice. Phenotypic characterization of splenic and islet-infiltrating.

RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development. RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development.

Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. Supplementation of c-Rel–competent Treg cells reverts.

Dynamic regulation of cell metabolism and mTORC1 activity and the requirement of RAPTOR in thymocyte development. Dynamic regulation of cell metabolism.

Induction of MHC-mismatched mixed chimerism depletes mature but not immature BM B cells by 60 days after HCT. Control and mixed chimeric NOD mice were.

Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice.

Loss of Tfh and GC B cells in 2KO-Bcl6TC mice.

Volume 23, Issue 4, Pages (October 2005)

CT-26 colon cancer induces the recruitment of protumor mast cells and the accumulation of MDSCs. CT-26 colon carcinoma cells (2 × 105) were injected s.c.

CD49b+ cells from tumor-bearing mice are more prone to conversion into MDSCs compared with naive CD49b+ cells. CD49b+ cells from tumor-bearing mice are.

GC reaction is impaired in NOTCH2 knock-in mice.

TILs upregulate CD137 in an HIF-1α–dependent fashion.

Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex treatment. Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex.

CPI-444 enhances T-cell activation in MC38 tumors.

Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. Mice with a B cell–specific.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

IL35 regulation of tumor growth is accompanied by suppression of CD4+ effector T-cell activity and expansion of Tregs. IL35 regulation of tumor growth.

Presentation transcript:

Major hematopoietic cell populations in NOD mice are not affected by c-Rel deficiency. Major hematopoietic cell populations in NOD mice are not affected by c-Rel deficiency. Flow cytometric analysis of hematopoietic populations in thymus (A and B) and spleen (C and D) comparing NOD c-Rel+/+, heterozygous NOD c-Rel+/−, and homozygous NOD c-Rel−/− mice. A: Representative plots of CD4 vs. CD8 and TCRβ vs. TCRγδ from three independent experiments for thymocytes. B. Histogram summary of three experiments with percentages (mean ± SEM) for double-negative (DN), double-positive (DP), CD4, and CD8 single-positive subsets as well as γδT cells, showing normal distributions of thymocytes in all three mouse genotypes. C: Representative plots of CD4 vs. CD8, CD19 vs. TCRβ, CD11c vs. CD11b (gated on CD19− cells), and TCRγδ vs. CD3, for splenocytes. D: Histogram summary of three experiments with percentages (mean ± SEM) for CD19+ B cells, CD4+, CD8+, and γδT cells as well as CD11b+ myeloid cells, showing normal distributions of cells in all three mouse genotypes. FACS plots are representative of three experiments, and bar graphs represent the average of three mice per genotype. Parameswaran Ramakrishnan et al. Diabetes 2016;65:2367-2379 ©2016 by American Diabetes Association