ChREBPα enhances mitochondrial oxidative metabolism.

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ChREBPα enhances mitochondrial oxidative metabolism. ChREBPα enhances mitochondrial oxidative metabolism. A: INS1 cells were treated as indicated and cultured in 11 mmol/L glucose. Mitochondrial membrane potential was determined by TMRE labeling and confocal microscopy. Scale bars = 14 μm. B: The intensity of individual cells in images acquired by confocal microscopy (as shown in A) were quantified with ImageJ software. arb., arbitrary; MFI, mean fluorescence intensity. C: The OCR of INS1 cells cultured in 11 mmol/L glucose was measured using a Seahorse XFe96 analyzer. Oligo, oligomycin; R/A, rotenone and antimycin A. D–G: Graphs show basal respiration (D); maximal respiratory capacity (E) (calculated as the difference between FCCP-induced OCR and OCR after addition of the R/A mixture; OCR by nonmitochondrial organelles); the difference between basal OCR and the oligomycin-insensitive OCR (F), which is the OCR coupled to ATP synthesis; and the spare respiratory capacity (G), calculated by subtracting basal OCR from FCCP-induced OCR. The data shown are the mean ± SE (n = 3 or 4). *P < 0.05, ***P < 0.001. Anil Kumar et al. Diabetes 2018;67:1561-1575 ©2018 by American Diabetes Association