The lack of effect of denatonium to stimulate insulin release in the absence of extracellular Ca2+ or in the presence of 10 μmol/l nitrendipine. The lack.

Slides:



Advertisements
Similar presentations
Ca 2+ ‐ independent insulin exocytosis induced by α ‐ latrotoxin requires latrophilin, a G protein ‐ coupled receptor by Jochen Lang, Yuri Ushkaryov, Alfonso.
Advertisements

Extracellular Ca2+ influx is essential but not sufficient for BCR‐mediated SRF activation in WT DT40 cells. Extracellular Ca2+ influx is essential but.
Insulin and glucagon secretion: nondiabetic and diabetic subjects.
Alison M.J. Buchan, Paul E. Squires, Mark Ring, R.Mark Meloche 
Regulation of renal proximal tubular epithelial cell hyaluronan generation: Implications for diabetic nephropathy  Stuart Jones, Suzanne Jones, Aled Owain.
Mean daily glucose concentration and frequency of hypoglycemia in long-term care residents with type 2 diabetes. Mean daily glucose concentration and frequency.
HOMA calculations where glucose is mmol/L and insulin is mU/L
Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.
Overexpression of BTG2 resulted in an increase in hepatic gluconeogenesis. Overexpression of BTG2 resulted in an increase in hepatic gluconeogenesis. A:
Serial measurements of serum glucose, anion gap, serum carbon dioxide, and serum triglycerides throughout the patient's hospital stay. Serial measurements.
Comparison of the protective effects of R and S isomers of LA on insulin-stimulated 2-DG uptake. Comparison of the protective effects of R and S isomers.
Glucose, insulin, and AGE levels during an OGC before and after RT
Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and exocytosis. Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and.
A: Mean Kir6.2/SUR1 or Kir6.2-R50G/SUR1 conductance in the presence of 100 μmol/l ADP (▪), 100 μmol/l ADP + 2 mmol/l Mg2+ (), or 100 μmol/l ATP plus 2.
Exogenous CRP administration causes fasting hyperglycemia and hyperinsulinemia without altering body composition. Exogenous CRP administration causes fasting.
Plasma glucose (A) and glucose specific activity (B) during euglycemic clamp experiments. Plasma glucose (A) and glucose specific activity (B) during euglycemic.
TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin resistance. TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin.
Model for the regulation of insulin secretion in the β-cell stimulated by glucose and amino acids. Model for the regulation of insulin secretion in the.
Glucose infusion rate required to maintain the hyperglycemic clamp during the experimental period in sedentary and exercised dogs receiving basal or elevated.
Effect of PIs on insulin release by downstream insulin secretogogues.
PTx pretreatment abrogates the glucagonostatic effect of high glucose concentrations. PTx pretreatment abrogates the glucagonostatic effect of high glucose.
Models of the mechanisms by which sulfonylureas and glucose control glucagon release. Models of the mechanisms by which sulfonylureas and glucose control.
In the absence of SST, 20 or 30 mmol/L glucose stimulates glucagon release. In the absence of SST, 20 or 30 mmol/L glucose stimulates glucagon release.
Cell proliferations, ROS production, and ATP levels in HASMCs cultured under high-glucose condition. Cell proliferations, ROS production, and ATP levels.
Glycemia and glucose tolerance of RIP-N mice.
Attenuation of glucose-, ex-4–, and GIP-induced increases in NSCC current in β-cells from TRPM2-KO mice. Attenuation of glucose-, ex-4–, and GIP-induced.
Grg3 works with Pdx1 to repress α-cell genes and induce glucose-stimulated insulin secretion. Grg3 works with Pdx1 to repress α-cell genes and induce glucose-stimulated.
Odds of incident diabetes by OGTT insulin patterns according to subjects characterized by presence or absence of IGT or dichotomized at the median value.
Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells.
Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,
The underlying physiological basis of the HOMA model.
Inhibition of GCS-derived ganglioside biosynthesis results in increased insulin sensitivity in hypothalamic cells. Inhibition of GCS-derived ganglioside.
A–E: Adiponectin secretion is stimulated via adrenergic pathways in a Ca2+-independent manner. A–E: Adiponectin secretion is stimulated via adrenergic.
DHA suppresses the translocation of NFκB and ROS generation stimulated by excess glucose and palmitate. 3T3–L1 adipocytes were cultured in 5 or 25 mmol/l.
Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose.
Effect of blockade of the Fas receptor on glucose- and interleukin-1β–induced β-cell DNA fragmentation and proliferative activity. Effect of blockade of.
Extracellular Ca2+-dependent cAMP production.
Insulin sensitivity in athletes and sedentary normal-weight and obese, young, and old individuals. Insulin sensitivity in athletes and sedentary normal-weight.
Substrate oxidation and contractile performance of Akita hearts
Adoptive transfer of purified activated G9Cα−/−
GLP-1 and gastrin combination therapy induces immunoregulatory cell activity in NOD mice. GLP-1 and gastrin combination therapy induces immunoregulatory.
Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H or R1420C mutations. Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H.
Glucose stimulates GLP-1 secretion from the perfused rat intestine by a dose- and absorption-dependent manner. Glucose stimulates GLP-1 secretion from.
Mean (±SE) plasma glucose concentrations before, during, and after infusions of octreotide (with growth hormone) with saline (•), with insulin replacement.
Npas4 is a stress-induced factor in pancreatic β-cells.
A: Comparison of the glucose-dependent insulinotropic effects of efaroxan and phentolamine. A: Comparison of the glucose-dependent insulinotropic effects.
Food intake in response to central infusion of glucose (squares) or insulin (triangles) and in response to successive central infusion of insulin, insulin.
Effect of high glucose and agents that alter mitochondrial metabolism on ROS production and expression of COX-2 mRNA in HMCs. Cells were incubated with.
Functional promoter activity of the human COX-2 gene in HMCs
An anti-BTC neutralizing antibody and a metalloproteinase inhibitor suppress GLP-1-induced DNA synthesis in INS(832/13) cells. [3H]thymidine incorporation.
Glucose-stimulated insulin secretion, plasma glucagon levels, and pancreatic hormone contents. Glucose-stimulated insulin secretion, plasma glucagon levels,
Assay of ROS accumulation in cells exposed to high levels of glucose.
PKA inhibitors do not markedly affect the potentiation of glucose-induced insulin release by GLP-1. PKA inhibitors do not markedly affect the potentiation.
Summary of the new mechanistic findings of the present study.
Pioglitazone administration acutely inhibits insulin secretion and increases insulin clearance in Wistar rats. Pioglitazone administration acutely inhibits.
Chronic rapamycin treatment impairs β-cell mass and insulin clearance in rats. Chronic rapamycin treatment impairs β-cell mass and insulin clearance in.
Proportion of patients experiencing documented symptomatic hypoglycemia (blood glucose
ADCY5 targets nonmetabolic processes to alter Ca2+ responses.
DPP-4 enhances M1 polarization and inhibits M2 polarization in macrophages in an ROS-dependent manner. DPP-4 enhances M1 polarization and inhibits M2 polarization.
Effect of GSK-3 inhibitors on basal and insulin-stimulated glucose uptake in human muscle cells. Effect of GSK-3 inhibitors on basal and insulin-stimulated.
Metabolic parameters in the three groups of patients during l-arginine infusion. Metabolic parameters in the three groups of patients during l-arginine.
Curcumin-generated ROS activates Chk1 and Chk2 kinases.
Relationship between changes in mean fat cell volume and insulin sensitivity (M values) after gastric bypass of obese women. Relationship between changes.
Effects of vinegar (□) and placebo (⧫) on plasma glucose (A–C) and insulin (D–F) responses after a standard meal in control subjects, insulin-resistant.
Case report: male 63 years old with documented stenosis of the internal cerebral artery, diabetes duration 12 years, and treatment with 22 IU insulin glargine.
Median (interquartile range) of sensor glucose (A) and insulin delivery (B) during closed-loop (solid red line and red shaded area) and control period.
The hyperbolic relationship between fasting insulin and Si (A) and AIRg and Si (B) for NFG (FPG
Distribution of daily frequency of BGM
Postprandial glucose, insulin and glucagon-like peptide-1 (GLP-1) levels following carbohydrate-first (CF), carbohydrate-last (CL) and sandwich (S) meal.
Cumulative mean numbers of confirmed (plasma glucose ≤3
Presentation transcript:

The lack of effect of denatonium to stimulate insulin release in the absence of extracellular Ca2+ or in the presence of 10 μmol/l nitrendipine. The lack of effect of denatonium to stimulate insulin release in the absence of extracellular Ca2+ or in the presence of 10 μmol/l nitrendipine. The experiments were performed on HIT-T15 cells in the presence of 4 mmol/l glucose. Both glucose- and denatonium-stimulated release were inhibited by the absence of extracellular Ca2+ and by nitrendipine in the presence of extracellular Ca2+ (n = 4). *P < 0.02 vs. 4 mmol/l glucose; **P < 0.001 vs. 4 mmol/l glucose + denatonium. Susanne G. Straub et al. Diabetes 2003;52:356-364 ©2003 by American Diabetes Association