Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension.

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Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model† Erkinaro T. , Ma¨kikallio K. , Kavasmaa T. , Alahuhta S. , Ra¨sa¨nen J. British Journal of Anaesthesia Volume 93, Issue 6, Pages 825-832 (December 2004) DOI: 10.1093/bja/aeh273 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 1 Uterine artery volume blood flows (a), uterine artery vascular resistances (b), and uterine artery pulsatility indices (c) at baseline and during hypotension, vasopressor treatment, and vasopressor treatment after maternal volume loading. The values are mean±95% CI. There were significant differences in changes over time between the ephedrine and phenylephrine groups in uterine artery volume blood flow (interaction P=0.004) and uterine artery vascular resistance (interaction P=0.004). *Pairwise P<0.05 as compared with baseline. 1Missing values because of technical difficulties in data collection. British Journal of Anaesthesia 2004 93, 825-832DOI: (10.1093/bja/aeh273) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 2 Placental volume blood flows (a), placental vascular resistances (b), and umbilical artery pulsatility indices (c) at baseline and during hypotension, vasopressor treatment, and vasopressor treatment after maternal volume loading. The values are mean±95% CI. There was a significant difference in changes over time between the ephedrine and phenylephrine groups in umbilical artery pulsatility index (interaction P<0.001). *Pairwise P≤0.05 as compared with baseline. 1Missing values because of technical difficulties in data collection. British Journal of Anaesthesia 2004 93, 825-832DOI: (10.1093/bja/aeh273) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions