Herpesviridae Part II

Cytomegalic inclusion disease(CID)

تشخیص آزمایشگاهی کشت سلول: کمتر کاربرد دارد. سرولوژی تشخیص آنتی ژن ویروس PCR

HHV6 pathogenesis

HHV6 typically occur in early childhood. primary infection causes exanthem subitum (roseola infantum, or "sixth disease") the mild common childhood disease characterized by high fever and skin rash. The virus is associated with febrile seizures in children. Infections persist for life. Reactivation appears to be common in transplant patients and during pregnancy.

Roseola

گاما هرپس ویرینه

Close contact

Infectious Mononucleosis

EBV Mono

Diagnosis of Epstein-Barr Virus Symptoms Mild headache, fatigue, fever Triad: Lymphadenopathy, splenomegaly, exudative pharyngitis Other: Hepatitis, ampicillin-induced rash Complete blood cell count Hyperplasia Atypical lymphocytes (Downey cells) (T cells) Heterophile antibody (transient) EBV-antigen specific antibody

Oral Hairy Leukoplakia This lesion is a wart-like growth that develops on the tongue in some HIV-infected persons and transplant patients. It is an epithelial focus of EBV replication.

Burkitt's Lymphoma EBV is associated with the development of Burkitt's lymphoma (a tumor of the jaw in African children and young adults).

Nasopharyngeal Carcinoma This cancer of epithelial cells is common in males of Chinese origin.

Lymphoproliferative Diseases in Immunodeficient Hosts Immunodeficient patients are susceptible to EBV-induced lymphoproliferative diseases that may be fatal. From 1% to 10% of transplant patients develop an EBV-associated lymphoproliferative disorder, often when experiencing a primary infection.

HHV8 Kaposi’s sarcoma Herpes Virus (KSHV)