Symptom-pattern phenotype and pulmonary function in preschool wheezers

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

What drives prescription patterns in pediatric asthma management?

Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection Howard M. Rosenblatt,

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications Judie A. Howrylak, MD, Anne L.

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD

Clarification concerning amoxicillin skin testing

Effects of time, albuterol, and budesonide on the shape of the flow-volume loop in children with asthma Anand C. Patel, MD, Mark L. Van Natta, MHS, James.

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications Judie A. Howrylak, MD, Anne L.

Increased airway smooth muscle in preschool wheezers who have asthma at school age Ruth O'Reilly, MBChBBAO, Nicola Ullmann, MD, Samantha Irving, BSc,

Does atopic dermatitis cause food allergy? A systematic review

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Children with allergic and nonallergic rhinitis have a similar risk of asthma Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,

Exhaled Nitric Oxide Measurements From Different Analyzers

Mothers' anxiety during pregnancy is associated with asthma in their children Hannah Cookson, MB, ChB, Raquel Granell, PhD, Carol Joinson, PhD, Yoav Ben-Shlomo,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

Test for Respiratory and Asthma Control in Kids (TRACK): A caregiver-completed questionnaire for preschool-aged children Kevin R. Murphy, MD, Robert.

The National Biome Initiative: An allergy perspective

Physician needs in health informatics: Just ask the docs

Nonadherence to Asthma Treatment: Getting Unstuck

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications Judie A. Howrylak, MD, Anne L.

René van Gent, MD, Cornelis K. van der Ent, MD, PhD, Maroeska M

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Repeated Episodes of Anaphylaxis with Normal Serum Tryptase but Elevated Levels of Urinary Prostaglandin D2 Phillip Lieberman, MD The Journal of Allergy.

Reply Journal of Allergy and Clinical Immunology

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Patterns and predictors of atopic dermatitis disease control past childhood: An observational cohort study Katrina Abuabara, MD, MA, Ole Hoffstad, MS,

Roles of arginase variants, atopy, and ozone in childhood asthma

Symptom-based classification of wheeze: How does it work in infants?

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults Meghan F. Davis, PhD, Roger D. Peng, PhD,

What are the best outcome measurements for atopic eczema

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Comparison of asthma prevalence among African American teenage youth attending public high schools in rural Georgia and urban Detroit Dennis R. Ownby,

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

What is an “eosinophilic phenotype” of asthma?

Medication use in children with asthma in Finland from 1995 to 2006

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Geographic variability in childhood asthma prevalence in Chicago

One step forward, 2 steps back: The enigma of preschool wheeze

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Anina M. Pescatore, MSc, Cristian M

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection Howard M. Rosenblatt,

Measles and immunomodulation

William J. Sheehan, MD, Helen A

The Editors' Choice Journal of Allergy and Clinical Immunology

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Perception of risk associated with asthma research procedures among adolescents, parents, and pediatricians Robert D. Annett, PhD, Janet L. Brody, PhD,

Environmental factors and eosinophilic esophagitis

Negative affect, medication adherence, and asthma control in children

Safety and efficacy of repeated monthly carboplatin desensitization

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Symptom-pattern phenotype and pulmonary function in preschool wheezers Samatha Sonnappa, MD, FRCPCH, PhD, Cristina M. Bastardo, MD, Angela Wade, PhD, Sejal Saglani, MRCPCH, MD, Sheila A. McKenzie, FRCPCH, MD, Andrew Bush, FRCP, FRCPCH, MD, Paul Aurora, MRCPCH, PhD Journal of Allergy and Clinical Immunology Volume 126, Issue 3, Pages 519-526.e7 (September 2010) DOI: 10.1016/j.jaci.2010.04.018 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Comparison of FeNO values, MBW indices, and sRaw among healthy control subjects and current episodic (viral) and multiple-trigger wheezers. Note that multiple-trigger wheezers have significantly higher LCI, Scond, and sRaw values compared with healthy children and episodic (viral) wheezers. There is no difference between episodic (viral) wheezers and healthy children for any of the outcome measures. Journal of Allergy and Clinical Immunology 2010 126, 519-526.e7DOI: (10.1016/j.jaci.2010.04.018) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 LCI and Scond plotted against sRaw and Scond plotted against LCI. A, LCI plotted against sRaw. B, Scond plotted against sRaw. C, Scond plotted against LCI. Broken lines represent estimated upper 95% limits of normality calculated as the mean + 1.96 SD (7.42 for LCI, 0.045 for Scond, and 1.44 kPa/s for sRaw) based on data from healthy control subjects in this study. The gray shaded areas around the broken lines represent the 95% confidence limits for the estimated upper 95% limits of normality. Journal of Allergy and Clinical Immunology 2010 126, 519-526.e7DOI: (10.1016/j.jaci.2010.04.018) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Baseline and postbronchodilator (post-BD) pulmonary function in episodic (viral) wheezers (EW) and multiple-trigger wheezers (MTW) compared with healthy control subjects. Journal of Allergy and Clinical Immunology 2010 126, 519-526.e7DOI: (10.1016/j.jaci.2010.04.018) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions