Oral peanut immunotherapy in children with peanut anaphylaxis

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Presentation transcript:

Oral peanut immunotherapy in children with peanut anaphylaxis Katharina Blumchen, MD, Helen Ulbricht, Ute Staden, MD, Kerstin Dobberstein, John Beschorner, Lucila Camargo Lopes de Oliveira, MD, Wayne G. Shreffler, MD, PhD, Hugh A. Sampson, MD, Bodo Niggemann, MD, Ulrich Wahn, MD, Kirsten Beyer, MD Journal of Allergy and Clinical Immunology Volume 126, Issue 1, Pages 83-91.e1 (July 2010) DOI: 10.1016/j.jaci.2010.04.030 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study protocol. Black arrow, Visit (patient history/physical examination/blood drawing/SPT). Journal of Allergy and Clinical Immunology 2010 126, 83-91.e1DOI: (10.1016/j.jaci.2010.04.030) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Flow diagram of children with peanut allergy recruited into the study. Journal of Allergy and Clinical Immunology 2010 126, 83-91.e1DOI: (10.1016/j.jaci.2010.04.030) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Correlation of peanut-specific IgE and the tolerated peanut dose after OIT following the rush protocol. Shown is the inverse correlation between level of peanut specific IgE (kUA/L) at enrollment vs tolerated dose of peanut after 7 days of OIT after the rush protocol (P = .003; Spearman r = –0.6). Journal of Allergy and Clinical Immunology 2010 126, 83-91.e1DOI: (10.1016/j.jaci.2010.04.030) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Clinical responses after OIT following the long-term buildup protocol. Shown are the tolerated peanut doses at baseline DBPCFC and at final DBPCFC post-OIT following the long-term buildup protocol of 14 patients who completed the whole study. The horizontal line represents the median of tolerated peanut dose. ∗∗P < .01. Journal of Allergy and Clinical Immunology 2010 126, 83-91.e1DOI: (10.1016/j.jaci.2010.04.030) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Comparison of laboratory and SPT results pre-OIT at baseline DBPCFC, directly post-OIT, and 2 weeks off OIT before final DBPCFC. Shown are IL-5 (A), IL-4 (B), IL-2 (C), wheal size diameter (D), peanut-specific IgE (E), and IgG4(F) for 14 patients who completed the study (∗P < .05; ∗∗P < .01; ∗∗∗P < .001). Selected patients are marked (#) to follow the individual course. Journal of Allergy and Clinical Immunology 2010 126, 83-91.e1DOI: (10.1016/j.jaci.2010.04.030) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions