m6A identification method based on m6A sensitive RNA endoribonuclease

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Fig. 1 m6A identification method based on m6A sensitive RNA endoribonuclease. m6A identification method based on m6A sensitive RNA endoribonuclease. (A) Validation for the methylation sensitivity of endoribonuclease MazF by synthetic m6A-containing RNA oligonucleotide. (B) Validation for the methylation sensitivity of endoribonuclease ChpBK. (C) Various ratios of m6A-containing oligo mixed with unmethylated oligo digested by endoribonuclease. The m6A/A ratios of synthetic oligo are indicated to imitate practical RNAs with different m6A ratios. (D) Relative grayscale of proportionally mixed RNA oligo digested by endoribonuclease. (E) The schematic diagram of m6A-REF-seq. Zhang Zhang et al. Sci Adv 2019;5:eaax0250 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).