Gene expression profile after cardiopulmonary bypass and cardioplegic arrest Marc Ruel, MD, MPH, Cesario Bianchi, MD, PhD, Tanveer A Khan, MD, Shu Xu,

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Gene expression profile after cardiopulmonary bypass and cardioplegic arrest Marc Ruel, MD, MPH, Cesario Bianchi, MD, PhD, Tanveer A Khan, MD, Shu Xu, PhD, John R Liddicoat, MD, Pierre Voisine, MD, Eugenio Araujo, PhD, Helen Lyon, MD, Isaac S Kohane, MD, PhD, Towia A Libermann, PhD, Frank W Sellke, MD The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 5, Pages 1521-1530 (November 2003) DOI: 10.1016/S0022-5223(03)00969-3

Figure 1 Genes that were differentially expressed with a P value of .0253 or less after cardiopulmonary bypass (CPB) and antegrade cold blood cardioplegia in cardiac (left) and skeletal muscle tissues (right) (of 12,625 genes examined). These genes and the number expected to result from repeat testing alone were identified by method 1 described in the text. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1521-1530DOI: (10.1016/S0022-5223(03)00969-3)

Figure 2 Northern and Western blot analyses of mRNA expression and protein level of DUSP1 and CYR61 in atrial (heart) and skeletal muscle (Sk.M.) tissues, pre- and post-CPB and cardioplegia. mRNA expression and protein levels of DUSP1 and CYR61 were significantly increased in post- versus pre-CPB atrial samples, but not in the skeletal muscle. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1521-1530DOI: (10.1016/S0022-5223(03)00969-3)

Figure 3 Representative in situ hybridization images of DUSP1, pre- and post-CPB in atrial tissues. A post-CPB and cardioplegic arrest increase in DUSP1 expression was localized to the endothelium (arrowheads) and myocytes (small arrows). The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1521-1530DOI: (10.1016/S0022-5223(03)00969-3)