Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

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Presentation transcript:

Role of IL-7 in the regulation of T-cell homeostasis in partial DiGeorge syndrome Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M. Noroski, MD, Imelda C. Hanson, MD, William T. Shearer, MD, PhD, Javier Chinen, MD, PhD Journal of Allergy and Clinical Immunology Volume 123, Issue 4, Pages 960-962.e2 (April 2009) DOI: 10.1016/j.jaci.2009.01.002 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A-D, Correlation of TREC values and CD3+, CD4+, and CD4+CD45RA+ T-cell counts in all patients with pDGS. E-H, Patients with pDGS with “low T cells.” I-L, Patients with pDGS with “normal T-cells.” Journal of Allergy and Clinical Immunology 2009 123, 960-962.e2DOI: (10.1016/j.jaci.2009.01.002) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 The “low T cells” patient group had significantly lower TREC values and higher IL-7 levels than the “normal T cells” patient group. A and C, Median TRECs/1000 mononuclear cells and plasma IL-7 levels (in picograms per milliliter) were 26.0 and 7.3 in the “low T cells” group and 105.3 and 3.3 in the “normal T cells” group, respectively. B, IL-7 levels were inversely correlated with TRECs in children with pDGS. Stars represent the 2 patients with low TREC values and low IL-7 levels. Journal of Allergy and Clinical Immunology 2009 123, 960-962.e2DOI: (10.1016/j.jaci.2009.01.002) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions