The rise and fall of horror autotoxicus and forbidden clones J. Charles Jennette, Ronald J. Falk  Kidney International  Volume 78, Issue 6, Pages 533-535 (September 2010) DOI: 10.1038/ki.2010.237 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Normal immune homeostasis involves a balance between T cells, B cells, and antibodies that are reactive with self, non-self, or both. Disease results when there is an imbalance of immune responsivity with either too little immune defense against foreign pathogens (immune deficiency disease), more immune response to non-self antigens than is beneficial (allergic or hypersensitivity disease), or more immune response to self antigens than is beneficial (autoimmune disease). Kidney International 2010 78, 533-535DOI: (10.1038/ki.2010.237) Copyright © 2010 International Society of Nephrology Terms and Conditions