Alterations in epithelial permeability of the intestines of mice lacking afadin, nectin-2 and nectin-3. Alterations in epithelial permeability of the intestines.

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Serrano, ME1,2, Bartholomé, O

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Alterations in epithelial permeability of the intestines of mice lacking afadin, nectin-2 and nectin-3. Alterations in epithelial permeability of the intestines of mice lacking afadin, nectin-2 and nectin-3. (A) In vivo intestinal permeability was determined by serum concentration 4 hours after FITC-dextran gavage. Littermates from control (n=7) and afadin cKO mice (n=8) were analyzed; P<0.01. (B) Epithelial permeability in the intestines of control mice and mice lacking nectin-2 and/or nectin-3 was evaluated. Experiments were performed using wild-type (WT) littermates (WT, n=8; nectin-2 KO, n=4) (WT, n=7; nectin-3 KO, n=10). Control mice heterozygous for nectin-2 and nectin-3 (n=6), as well as double-knockout mice lacking both nectin-2 and nectin-3 (DKO) (n=10), were all littermates. No significant change was observed in the serum FITC-dextran levels between the three groups of mouse genotypes. Miki Tanaka-Okamoto et al. J Cell Sci 2011;124:2231-2240 © 2011.