Survival of the Fittest: Darwinian Selection Underpins Chemotherapy Resistance in AML  Laura MacPherson, Mark A. Dawson  Cell Stem Cell  Volume 21, Issue 3, Pages 291-292 (September 2017) DOI: 10.1016/j.stem.2017.08.004 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Schematic of the Two Major Patterns of Relapse in AML (A) Relapse origin-primitive (ROP). Relapse was traced to rare immature HSPC-like leukemia cells that were chemoresistant. This pattern demonstrates a deep hierarchal organization whereby only a rare population of HSPC-like leukemia cells express a stem cell program. (B) Relapse origin-committed (ROC). Relapse was traced to a more mature CD33+ blast population with a strong LSC-like transcriptional program. This pattern of relapse demonstrates a shallow hierarchal organization. The CD33+ blast population that persists post-therapy could be potentially targeted with anti-CD33 maintenance. Cell Stem Cell 2017 21, 291-292DOI: (10.1016/j.stem.2017.08.004) Copyright © 2017 Elsevier Inc. Terms and Conditions