Eyal Grunebaum, MD, Ernest Cutz, MD, Chaim M. Roifman, MD

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Presentation transcript:

Pulmonary alveolar proteinosis in patients with adenosine deaminase deficiency Eyal Grunebaum, MD, Ernest Cutz, MD, Chaim M. Roifman, MD Journal of Allergy and Clinical Immunology Volume 129, Issue 6, Pages 1588-1593 (June 2012) DOI: 10.1016/j.jaci.2012.02.003 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Lung sample from a patient with ADA deficiency. A, Hematoxylin and eosin staining demonstrating alveolar spaces filled with homogeneous eosinophilic material. B, Immunostaining with antibodies to surfactant protein A demonstrating positive immunoperoxidase reaction (brown) of intra-alveolar material. C, Electron micrograph demonstrating alveolar surfactant composed of concentric lamellar bodies. D, Electron micrograph at higher magnification showing a lamellar body with characteristic phospholipids. Journal of Allergy and Clinical Immunology 2012 129, 1588-1593DOI: (10.1016/j.jaci.2012.02.003) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions