PGC-1α isoforms. PGC-1α isoforms. A, The illustration of PGC-1α new alternative exons and known exons in RefSeq/Ensembl/UCSC genome references. Human ESTs.

Slides:

Advertisements

Similar presentations

Rupp et al. Supplementary Figure 1: Structure of the human troponin T gene Exon 6 Genomic DNA cDNA from mRNA mutation Exon 9 Exon bp Parts of genomic.

Advertisements

Volume 2, Issue 10, Pages (October 2015)

Molecular Therapy - Nucleic Acids

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

Lack of gp130 expression in hepatocytes promotes liver injury1

Dendritic spine density at P30 is elevated on isolated PirB−/− neurons in layer 2/3 after sparse excision of PirB at E15.5. Dendritic spine density at.

Cocaine exposure downregulates miR-125b expression.

Surface renderings of the brain activation showing significant activation in the general mixed design ANOVA for the interaction between all three factors,

Volume 6, Issue 2, Pages (January 2014)

Fiber innervation is reduced in both central and peripheral targets of DRG neurons in Nav-Tsc2 mice. Fiber innervation is reduced in both central and peripheral.

Chemogenetic modulation of vlPAG glutamatergic neurons bidirectionally modulates nociceptive behaviors. Chemogenetic modulation of vlPAG glutamatergic.

Viral genetic targeting of hilar mossy cells for rabies-based mapping of circuit connections in vivo. Viral genetic targeting of hilar mossy cells for.

Examining effects of different microscopes to image clear brains.

Marker genes are selected for mouse brain cell types and used to estimate cell type profiles. Marker genes are selected for mouse brain cell types and.

qRT-PCR validation of differential expression.

The effect of ETC duration and temperature on imaging depth.

Upper cortical layer-enriched neuronal expression of HA-UPRT.

Sparse excision of PirB at E15

Neuronal ATM level is reduced in mouse models of AD

Production of Mapk14 and Mapk7 KO cells.

Mean C-to-U editing ratios for most editing sites map to a region on chromosome 6 at 122 Mb. (A) Genome scan of mean C-to-U editing for 70 editing sites.

Morphologic and functional evaluation of adult conditional PGC-1 knockout mice. Morphologic and functional evaluation of adult conditional PGC-1 knockout.

Both sexual experience and ΔFosB increase dendritic spines in vmPFC.

Targeted disruption of the RapGEF2 gene.

Changes throughout time in the lineage content of clones regenerated in secondary mice. Changes throughout time in the lineage content of clones regenerated.

Changes in WM diffusion parameters with increasing age along the length of HG from medial (primary) to lateral (nonprimary). Changes in WM diffusion parameters.

Sequences of two isoforms of Arhgap39/Porf-2 protein in mouse.

Fig. 1. Generation of WNK3 knockout mice

Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours. Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours.

α-Cells mainly express SSTR2 and SSTR3

Gα12 is not required for hepatic cystogenosis induced by Pkd1 knockout

Adult conditional gene deletion of PGC-1α.

CRISPRa induction of Bdnf transcript variants I and IV in primary rat hippocampal neurons. CRISPRa induction of Bdnf transcript variants I and IV in primary.

Efficient In Vivo Liver-Directed Gene Editing Using CRISPR/Cas9

The complexity as well as the total dendritic length of ApoE-deficient adult-born granule cells are significantly reduced. The complexity as well as the.

The complexity and the total dendritic length of ApoE4 adult-born granule cells are significantly reduced. The complexity and the total dendritic length.

Altered luminal pH of the Golgi apparatus in GPHR deficient primary cultured neurons. Altered luminal pH of the Golgi apparatus in GPHR deficient primary.

Effect of FGF8 on R-C marker expression.

Targeted disruption of the mouse Atp1a2.

Csmd2 mRNA is expressed in the mouse forebrain.

Chronological changes of pSer46-MARCKS in human α-Syn-BAC-Tg/GBA-hetero-KO mice. pSer46-MARCKS and pSer129-α-Syn were costained in human normal α-Syn-BAC-Tg/glucocerebrosidase.

A subset of nNOS+ interneurons derive from the CGE and coexpresses VIP

Aβ-mediated Ras-MAPK signaling and Cyclin D1 expression in B103 cells are dependent on APP expression and can be reversed with MEK or Ras inhibition. Aβ-mediated.

Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. A,

Reduction of PGC-1α isoforms, SDHA, and Tomm20 in PD

NCS-Rapgef2-dependent ERK activation in mouse NAc following D1 dopamine receptor agonist SKF and psychostimulants D-amphetamine or cocaine administration.

BNST AVP cell ablations in iCre+ animals did not influence anxiety-like behavior. BNST AVP cell ablations in iCre+ animals did not influence anxiety-like.

Alterative splicing and tissue distribution.

Regional and cellular differences in Kcnq4 transcripts in the cochlea.

GFP is expressed selectively in NPY neurons.

Dissection and clearing of brain subregions.

TRAF6 enhances I/R-induced oxidative stress.

Generation of an inducible tissue-specific Atoh1 transgenic mouse line

Method for anatomical characterization and quantification of arterial lumen and PVS. a, A three-dimensional image stack is obtained using two-photon microscopy.

Expression of Chx10-cre and phenotypes of Chx10-cre induced Smo ablation. Expression of Chx10-cre and phenotypes of Chx10-cre induced Smo ablation. A–G,

Effects of the genotypes of Rapgef2 and Rapgef6 on the distribution of neural progenitor cells. Effects of the genotypes of Rapgef2 and Rapgef6 on the.

A, B, Startle magnitude and PPI after treatment with CNO

Topographic organization of CA3 to CA1 projections revealed through monosynaptic rabies tracing by specifically targeting CA1 pyramidal cells along the.

Spatial cues direct neuronal diversification with respect to OR gene selection. Spatial cues direct neuronal diversification with respect to OR gene selection.

AVP histology and experiment timeline.

TERT promoter mutations and telomerase reactivation in urothelial cancer by Sumit Borah, Linghe Xi, Arthur J. Zaug, Natasha M. Powell, Garrett M. Dancik,

Bcl-XL upregulates the expression of genes characteristic to midbrain and hindbrain fates during in vitro differentiation of ES cells. Bcl-XL upregulates.

FMRP S499 rephosphorylation kinetics after CX-4945 treatment and washout mirrors a known CK2 target. FMRP S499 rephosphorylation kinetics after CX-4945.

BORIS mRNA expression in DNMT deficient HCT116 cell lines.

E-stimulation of the olfactory nerve evokes PGC inhibitory responses in distant glomeruli. E-stimulation of the olfactory nerve evokes PGC inhibitory responses.

Grand-averaged ERPs across (A) left hemisphere electrodes (P5, P7, P9, PO3, PO7, and O1) and (B) right hemisphere electrodes (P6, P8, P10, PO4, PO8, and.

H19 was essential for cancer metastasis.

Coexpression of Crf and Tac2 (A-P -1.5).

The expression of miR-9 and miR-140-5p in Area X is regulated during vocal development. The expression of miR-9 and miR-140-5p in Area X is regulated during.

Fig. 3 Correction of Dmd exon 44 deletion in mice by intramuscular AAV9 delivery of gene editing components. Correction of Dmd exon 44 deletion in mice.

Presentation transcript:

PGC-1α isoforms. PGC-1α isoforms. A, The illustration of PGC-1α new alternative exons and known exons in RefSeq/Ensembl/UCSC genome references. Human ESTs and mouse TSS with enhancer signals derived from >1000 human and mouse primary cells, cell lines, and tissues were mapped using CAGE. B, Diagram and PCR products show four different PGC-1α isoforms from SH-SY5Y and mouse brain and heart. C, RT-PCR for four PGC-1α isoforms, SDHA, Tomm20, and GAPDH RNA 4 weeks after stereotactic delivery of AAV-GFP or AAV-Cre-GFP into PGC-1αflox/flox mice; n = 3/group. D, Quantification of C normalized to GAPDH; n = 3/group. *p < 0.05, **p < 0.005. Haisong Jiang et al. eneuro 2016;3:ENEURO.0183-16.2016 ©2016 by Society for Neuroscience