B cells and tertiary lymphoid organs in renal inflammation

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B cells and tertiary lymphoid organs in renal inflammation S. Segerer, D. Schlöndorff Kidney International Volume 73, Issue 5, Pages 533-537 (March 2008) DOI: 10.1038/sj.ki.5002734 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Hypothetical scheme of the development of TLOs in the kidney during chronic injury. This has been detailed according to the review by Aloisi and Pujol-Borrel18 and is mainly based on extrarenal data on the formation of tertiary lymphatic organs. After an initial insult (a) inflammatory cells are recruited and promote further inflammation. (b) With the progression of chronic renal injury, macrophages, B cells, T cells, and potentially DCs accumulate in the tubulointerstitium. During interstitial injury, release of modified tubulointerstitial antigens might promote persisting inflammation. (c) With the interaction between intrinsic renal cells and interstitial inflammatory cells, tertiary lymphatic organs form, surrounded by newly formed lymphatic vessels. Kidney International 2008 73, 533-537DOI: (10.1038/sj.ki.5002734) Copyright © 2008 International Society of Nephrology Terms and Conditions